摘要
目的分析和探讨单核细胞趋化蛋白-1(MCP-1)在由HPV感染而发生宫颈癌患者表达情况,进一步对临床治疗宫颈癌疾病提供理论指导。方法选取2013年10月-2015年10月在医院接受治疗60例由HPV感染而发生宫颈癌的患者作为研究对象,将正常宫颈上皮细胞作为对照组,宫颈癌变细胞作为观察组,各60份;比较两组患者MPC-1的表达情况,数据采用SPSS 16.0软件进行统计分析。结果观察组MCP表达为阳性的标本所占比例是71.67%,对照组MCP表达为阳性所占比例是35.00%;观察组患者中强阳性和阳性所占的比例明显高于对照组,差异均有统计学意义(P<0.05)。结论在宫颈癌细胞中,MCP-1的表达率明显高于其他组织细胞,MCP-1在HPV感染导致的宫颈癌发展过程中起着重要作用,MCP-1给合临床早期诊断宫颈癌提供帮助。
OBJECTIVE To analyze and discuss the impression of monocyte chemoattractant protein-1（MCP-1）in the development of cervical cancer caused by HPV infection so as to provide theoretical guidance to improve the treatment efficiency of cervical cancer.METHODS Totally 60 cases with cervical cancer caused by HPV infection admitted in the hospital from Oct.2013 to Oct.2015 were chosen as study objects.The normal cervical epithelial cells were regarded as control group and cervical cancer cells were treated as observation group,with 60 samples in each group.The expressions of MPC-1were compared in the two groups and all data were statistically analyzed by SPSS 16.0.RESULTS Positive MPC expression samples of the observation group accounted for 71.67%,while it was 35.00%in the control group.Proportion of super positive and positive samples in the observation group were significantly higher than the control group（P〈0.05）.CONCLUSION The expressions of MCP-1in the cervical cancer cells were significantly higher than other cells.MCP-1plays an important role in the development of cervical cancer caused by HPV infection,hence can be used to make early diagnosis of cervical cancer.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第16期3786-3787,3796,共3页
Chinese Journal of Nosocomiology
基金
安徽省卫生厅医学科研重点基金资助项目(2010A003)
