妊娠期HPV病毒感染和宫颈鳞状上皮内瘤变的相关性研究

Correlation between human papillomavirus(HPV)infection and cervical intraepithelial neoplasia after pregnancy

目的探讨妊娠期HPV感染与宫颈鳞状上皮内瘤变风险及病理分级之间关联性,为临床治疗提供参考依据。方法回顾性分析2012年1月-2015年3月在医院门诊就诊的2 475名非妊娠妇女,将所有受试者调查期间分未孕随访组2380名,孕后随访组27名;分析HPV感染与宫颈鳞状上皮内瘤变之间的关系,数据采用SPSS18.0软件进行统计分析。结果本研究共记录了95名妇女在随访期间怀孕,其中27名妇女在产后接受了随访,而另外68名妇女则拒绝妊娠后随访;在27名产后随访对象中,仅出现1例高级别鳞状上皮内瘤变;在未孕组和产后继续随访组的比较中,发现妊娠与低级别鳞状上皮内瘤变和任何等级鳞状上皮内瘤变都无任何关联。结论妊娠与HPV感染、宫颈鳞状上皮内瘤变之间并无显著关联。

OBJECTIVE To investigate the possible relationship of HPV infection and cervical intraepithelial neoplasia as well as pathological grading after pregnancy,so as to provide references for clinical treatment.METHODS A total of 2475 women without pregnancy from Jan.2012 to Mar.2015 were enrolled in the study,and divided into2380 cases of unpregnancy follow-up group and 27 cases of post-pregnancy follow-up group.The correlations between pregnancy and HPV infection or cervical intraepithelial neoplasia were analyzed.The data were analyzed by SPSS 18.0.RESULTS Totally 95 women with pregnancy during follow-up,27 patients received the whole followup,and 68 patients with pregnancy refused the follow-up after childbirth.Only one HSIL case occurred after pregnancy.Likewise,there was no association between pregnancy and risk of low grade SIL or any-grade SIL at the next visit.CONCLUSIONThere was no correlation between pregnancy and HPV infection and LSIL.