坏死性小肠结肠炎并发败血症的患儿临床治疗研究

Clinical treatments of children with necrotizing enterocolitis combined with septicemia

目的探讨坏死性小肠结肠炎并发败血症患儿的临床特点以及危险因素,为临床提供理论指导与依据。方法选取2012年9月-2015年9月在医院接受治疗的确诊为坏死性小肠结肠炎并发败血症新生儿60例为研究对象,对其临床资料进行回顾性分析,对其治愈率与预后相关进行分析。结果早产、体重偏轻、人工喂养、败血症、肺炎、呼吸缓慢或暂停、休克、腹膜肿胀、高血糖、酸中毒、肠穿孔为坏死性小肠结肠炎并发败血症相关因素,与治愈率相关;影响患儿预后不良的多因素logistic回归表明,患儿早产、酸中毒是预后不良的主要危险因素(P<0.05)。结论临床上新生儿坏死性小肠结肠炎并发败血症的危险因素较多,应结合相关因素积极预防。

OBJECTIVE To explore the clinical characteristics and risk factors of necrotizing enterocolitis combined with septicemia in children so as to provide theoretical guidance and basis for clinical treatments.METHODS Totally 60 neonates diagnosed as necrotizing enterocolitis combined with neonatal sepsis admitted from Sep.2012 to Sep.2015 were chosen as study objects.Their clinical data,recovery rates and prognosis were retrospectively analyzed.RESULTS Premature birth,underweight,artificial feeding,septicemia,pneumonia,slow breathing or suspend,shock,abdominal swelling,high blood sugar,acid poisoning,and intestinal perforation were risk factors for patients with necrotizing enterocolitis complicated with sepsis.Multivariate logistic regression analysis showed that premature infants and acidosis were main risk factors of poor prognosis（P〈0.05）.CONCLUSIONThere are many risk factors causing neonatal necrotizing enterocolitis complicated with sepsis,which should be prevented accordingly.