药学干预对中药注射剂合理使用的影响分析

Analysis of the Effect of Pharmaceutical Intervention on Rational Use of TCM Injection

目的:为中药注射剂合理使用提供参考。方法:选取我院2014年7-12月使用中药注射剂的住院病历487份作为对照组,选取2015年1-6月使用中药注射剂的住院病历500份作为干预组。比较两组中药注射剂的使用情况、用药合理性及不良反应情况。结果:通过临床药师的干预,我院销售金额排序前10位的中药注射剂的销售金额和使用数量明显降低。干预组5个类型共26个品种中药注射剂的不合理使用率(21.60%vs.43.33%)及不良反应发生率(3.00%vs.7.39%)明显降低,与对照组比较差异均有统计学意义(P<0.05)。干预组人均治疗费用[(217.17±22.64)元vs.(480.77±21.35)元]及住院时间[(6.50±1.99)d vs.(10.02±3.25)d]显著少于或短于对照组,差异均有统计学意义(P<0.05)。结论:实施药学干预可以强化临床医师合理应用中药注射剂的意识,提高合理用药的水平,减少不良反应,降低治疗费用。

OBJECTIVE：To provide reference for the rational use of TCM injections. METHODS：487 medical records using TCM injection in our hospital from Jul. to Dec. 2014 were selected as control group,another 500 from Jan. to Jun. 2015 were intervention group. Utilization,rationality and adverse reactions of TCM injection between 2 groups were compared. RESULTS：According to the intervention by clinical pharmacists,the sales amount and utilization rate of top 10 TCM injection in our hospital were lower significantly. The irrational utilization rate of 5 types（totally 26 varieties） in intervention group decreased（21.60% vs.43.33%）,incidences of adverse reactions reduced（3.00% vs. 7.39%）,compared with control group,the differences were statistically significant（P〈0.05）. Treatment cost per capita [（217.17 ± 22.64）yuan vs.（480.77 ± 21.35）yuan] and hospitalization time[（6.50 ± 1.99）d vs.（10.02 ± 3.25）d] in intervention group were significantly lower or shorter than control group,the differences were statistically significant（P〈0.05）. CONCLUSIONS：Implementing pharmaceutical interventions can strengthen the sense of clinicians＇ rational use of TCM injection,raise the level of rational use of drugs and reduce adverse reactions and medical errors.