载药同轴静电纺玉米醇溶蛋白/聚乙烯醇-苯乙烯基吡啶盐缩合物复合纳米纤维的制备及性能

Preparation and Characterization of Drug-Loaded Co-Axial Electrospun Zein / PVA-SbQ Composite Nanofibers

采用同轴静电纺丝法制备了以盐酸四环素作为模型药的载药玉米醇溶蛋白(Zein)/聚乙烯醇-苯乙烯基吡啶盐缩合物(PVA-SbQ)复合纳米纤维,以紫外光照作为后处理。分别通过透射电镜、扫描电镜、傅里叶变换红外光谱仪、差示量热扫描仪、X射线衍射仪、万能试验机表征和分析了纤维结构和形貌、化学组成、药物分散形式和力学性能。药物体外释放实验表征了该纳米纤维膜的药物释放性能,并对药物释放曲线进行了数学模型拟合。结果显示,同轴静电纺纤维成形良好,具有明显的皮芯层结构,各组分保持物理混合状态,药物以无定形形式分布于纤维中,PVA-SbQ的加入有利于改善纤维膜力学性能,同轴复合纳米纤维膜能缓解药物突释的现象,其药物释放机理与一级释放模型较为接近。

Using tetracycline hydrochloride （TH） as model drug, drug-loaded zein/polyvinyl alcohol bearing styrylpyridinium group （PVA-SbQ） composite nanofibers were prepared through co-axial electrospinning with ultraviolet（UV） illumination as post treatment. The structure and surface morphologies, chemical composition, dispersive form of drug and mechanical strength of the nanofibers were characterized through TEM and SEM, FT-IR, DSC, XRD and electro-mechanical universal testing machines, respectively. In vitro drug release test and mathematical fitting were also performed to investigate drug release properties. Results show that nanofibers with core-shell structure are successfully formed. Materials are physically combined. Tetracycline hydrochloride is loaded in an amorphous form in nanofibers. The addition of PVA-SbQ is conducive to the improvement of mechanical strength. Initial release burst is alleviated and the drug release mechanism conforms to first-order model.