异常体液分型的口腔扁平苔藓病损组织中RANTES含量的变化

Observation of RANTES in various types of abnormal humour syndrome patients with oral lichen planus

目的观察异常体液型OLP病损组织中T细胞表达和分泌的活性调节蛋白(RANTES)含量的变化,探讨RANTES在OLP维吾尔医学异常体液分型中的临床意义。方法对本院门诊就诊的76例OLP患者进行异常体液分型分组,采用免疫组化SP法检测OLP组织中RANTES的表达水平。结果 OLP患者中异常血液质51例(67.11%)、异常胆液质6例(7.89%)、异常黏液质15例(19.74%)、异常黑胆质4例(5.26%);RANTES在不同体液质型的表达为异常血液质52.63%、异常胆液质7.89%、异常黏液质14.47%,异常黑胆质中不表达。结论异常血液质与OLP的发生发展可能存在一定关系,RANTES可能可以作为异常血液质OLP的靶向指标。

Objective To observe the changes of regulated upon activation normal T cell expressed and secreted factor（ RANTES）concentrations in various abnormal humour（ Hilit） syndrome patients with oral lichen planus（ OLP）,and to explore the clinical significance in the classification of OLP by the humour theory of traditional Uighur medicine（ TUM）. Methods 76 cases of OLP patients were classified according to the classification of abnormal humour. Biopsies were collected from 76 patients with OLP lesions. Expressions of RANTES were determined by the streptavidin-peroxidase（ SP） technique. Results There were 51（ 67.11%） cases of abnormal Khan syndrome,6（ 7. 89%） cases of abnormal Sapra syndrome,15（ 19. 74%） cases of abnormal Balgham syndrome,and 4（ 5.26%） cases of abnormal Sawda syndrome among the 76 cases of OLP patients. Expressions of RANTES in different abnormal humour syndrome patients with OLP were 52.63% in abnormal Khan syndrome,7.89% in abnormal Sapra syndrome,and 14.47% in abnormal Balgham syndrome groups. Conclusion There might be possible correlation between abnormal Khan syndrom and OLP. RANTES may play a role in OLP process.