腔隙性脑梗死患者眼底动脉硬化分级与部分脑动脉硬化危险因素变化的相关性研究

Correlations between retinal artery atherosclerosis classification and risk factors for cerebral arteriosclerosis in lacunar infarction patients

目的探讨腔隙性脑梗死(LI)患者眼底动脉硬化分级与部分脑动脉硬化危险因素变化的相关性。方法以我院收治的LI患者中随机选取110例患者为研究对象均行眼底照相检查,对患者的眼底动脉硬化进行分级,检测并观察患者的血压(BP)、LI病灶数及其受累部位数、颈动脉斑块面积、血糖(Glu)、同型半胱氨酸(Hcy)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、颈动脉内-中膜厚度(IMT)等指标。结果动脉硬化改变的有108例。眼底动脉硬化轻度组在收缩压(SBP)、LI病灶数及其受累部位数、颈动脉斑块面积、Glu值、IMT方面,均显著优于中重度组,差异具有统计学意义(P<0.05);且眼底动脉硬化与以上多种因素均有良好相关性。经分析发现,患者的眼底动脉硬化程度与LI病灶数及其受累部位数的关系更加密切;另外,两组的Glu值差异也具有统计学(P<0.05)。结论 LI患者眼底动脉硬化分级与患者的SBP、LI病灶数及其受累部位数、颈动脉斑块面积、Glu值、IMT等因素具有密切相关性,在临床诊断和治疗当中,可以将以上多种因素作为眼底动脉的观察指标。

Objective To study the relationships between fundus arteriosclerosis classification and risk factors for cerebral arteriosclerosis in lacunar infarction patients. Methods A total of 110 hospitalized patients diagnosed with cerebral lacunar infarction（ LI） were involved in this study. Fundus photograph was taken from the patients and arteriosclerosis was graded. Authors also investigated systolic blood pressure（ SBP）,number of LI lesions,affected sites,carotid artery plaque area and intima-media thickness（ IMT）,serum levels of glucose,homocysteine,and lipid profiles. Results Retinal artery arteriosclerosis existed in 108 patients. Patients with mild fundus arteriosclerosis had significantly better results in SBP,carotid artery plaque area,IMT,LI lesions,affected sites,and serum biomarkers（ P〈0. 05）. Classification of fundus atherosclerosis had good correlations with these factors. Our analysis found that number of LI lesions and affected sites were the strongest correlated factors. Conclusion The degree of fundus arteriosclerosis in LI patients was closely associated with a group of factors that are common for systemic cardio- and cerebral vascular diseases.