HBVDNA载量与肝硬化和原发性肝癌的相关性探究

Correlation between HBV DNA load and liver cirrhosis,hepatocellular

目的探讨乙型肝炎病毒(HBV)DNA载量与肝硬化和原发性肝癌的相关性。方法选择乐山市人民医院2014年3月到2015年3月的住院患者中感染HBV的患者552例,用实时荧光定量PCR检测其入院时的HBV DNA载量,根据临床诊断分别统计阳性组与阴性组中肝硬化和原发性肝癌患者例数。结果统计显示DNA阳性组345例,DNA阴性组207例,DNA阳性组的肝硬化患病率为44.93%,DNA阴性组的肝硬化患病率为35.75%,差异有统计学意义(P<0.05)。DNA阳性组的原发性肝癌患病率为8.12%,DNA阴性组的原发性肝癌患病率为7.25%,差异无统计学意义(P>0.05)。结论感染HBV病毒的患者HBV DNA载量与肝硬化的发生有关,与原发性肝癌的关系仍需进一步探讨。

Objective To investigate the correlation between hepatitis B virus deoxyribonucleic acid （HBV DNA） load and liver cirrhosis,hepatocellular carcinoma （PHC）. Methods We chose 552 cases with hepatitis B virus infection in Leshan peoplers hospital from 2014 March to 2015 March,and used real-time fluorescence quantitative PCR to detect the HBV DNA load. According to the results, patients were divided into DNA positive group and DNA negative group. The two groups of patients with liver cirrho- sis and primary liver cancer patients were statistically analys.ed separately. Results There were 345 patients in DNA positive group while 207 patients in DNA negative group. Cirrhosis prevalence rate of DNA positive group was 44.93%, while the rate of DNA negative group was 35.75 %, and there was significant difference between them（P〈0. 05）. Hepatocellular carcinoma prevalence rate of DNA positive group was 8.12% ,while the rate of DNA negative group was 7.25% ,and there was no significant difference between them（P〉0.05）. Conclusion Hepatitis B virus DNA load in the patients infected by HBV is connected with the occurrence of liver cirrhosis,but the relationship with the hepatocellular carcinoma is still need to be further discussed.