非小细胞肺癌中胰岛素样生长因子-1受体表达的临床意义

Clinical Value of Insulin-like Growth Factor-1 Receptor Expression in Non-small Cell Lung Cancer

目的探讨胰岛素样生长因子-1受体(IGF-1R)表达与非小细胞肺癌(NSCLC)患者临床特征以及术后辅助化疗远期疗效的关系。方法 122例NSCLC患者均接受肺癌完全性切除术,采用免疫组化法检测所有患者癌组织以及其中48例患者的癌旁正常组织中IGF-1R表达情况。结果 NSCLC组织中IGF-1R表达阳性率显著高于癌旁正常组织,差异有显著性(P<0.01)。IGF-1R阳性表达与患者性别、年龄、组织学类型、组织学分级、吸烟史无相关性(P>0.05),与肿瘤直径、临床分期、淋巴结转移显著相关(P<0.05)。IGF-1R阳性组中位无进展生存期(m DFS)、中位总生存时间(m OS)显著短于IGF-1R阴性组,差异有显著性(P<0.05)。结论 NSCLC中IGF-1R表达与其临床特征指标有一定的关系,且对患者的预后有影响。

Objective To investigate the relationship between expression of insulin-like growth factor-I receptor （ IGF- 1 R） and clinical characteristics indexes,long-term efficacy of postoperative adjuvant chemotherapy in patients with non-small cell lung cancer （NSCLC）. Methods 122 cases of patients with NSCLC were selected, and all patients received complete resection of lung cancer, then the IGF-1R expression in 122 cases of lung cancer tissues and 48 eases of adjacent normal tissues were detec- ted by immunohistoehemical method. Results The positive rate of IGF-1R expression in NSCLC tissues was statistically higher than that of adjacent normal tissues （ P 〈 0.01 ）. IGF-1R positive expression was not related with gender, age, histological type, histological grade, and smoking history （ P 〉 0.05 ）, but was related with tumor size, clinical stage, and lymph node metastasis （ P 〈 0.05）. The median progression-free survival （mDFS） and median overall survival（mOS） in IGF-1 R positive group were sta- tistically shorter than those of IGF-1R negative group, there had statistical differences between the 2 groups （ P 〈 0.05 ）. Conclu- sion The expression of IGF-1R is related to clinical characteristics indexes and prognosis of patients with NSCLC.