摘要
疼痛作为最常见的临床症状之一,严重影响患者的生活质量。瞬时感受器电位受体TRPV1与嘌呤类受体P2X3均参与多种病理性疼痛信号的传导,具有多种活化形式。两者间的相互作用报道较少。文中就TRPV1与P2X3参与疼痛信号传导的相互作用进行综述,为疼痛的治疗研究提供新的途径。
Pain, as one of the most common clinical symptoms, seriously affects the quality of life of patients. Transient Re- ceptor Potential Vanilloid Type 1 （ TRPV1 ） and Purinergic receptor（ P2X3 ） are both involved in the transmission of a variety of patho- logical pain signals. Their interaction is less reported. This article reviews the interaction between TRPV1 and P2X3 in the pain signal transduction, and provides a new way for the treatment of pain.
出处
《医学研究生学报》
CAS
北大核心
2016年第8期868-871,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金(81473772)
浙江省医药卫生重大科技计划项目(WKJ-ZJ-1419)
浙江省自然科学基金(LQ15H270003)
浙江省医药卫生科技项目一般项目(2015KYB281)
关键词
疼痛
P2X3
瞬时感受器电位受体1
相互作用
Pain
P2X3
Transient receptor potential channel vanilloid type 1
Interaction
