粪菌移植在溃疡性结肠炎治疗中的临床应用

Clinical application of fecal microbiota transplantation on ulcerative colitis

粪菌移植最早起源于2700年前春秋战国时期,但用于溃疡性结肠炎的治疗目前仍处于起步阶段。其移植流程主要包括供体的选择、菌液制备及粪菌液的导入等。该治疗方式无严重不良反应,相对安全。关于其有效性各研究结论不一,可能与适应证的选择、供体的选择、移植流程等缺乏统一的标准有关。

Fecal bacteria transplantation（FMT） originated in the Spring and Autumn Period and Warring-- States Period 2700 years ago, however, its treatment on ulcerative colitis is still in infancy. The process of FMT mainly includes the selection of the donor, preparation of the bacterial liquid and introduction of the liquid. The treatment has no serious side effects, and is relatively safe. But, its effect is not as remarkable as in Clostridium difficile infection＇s treatment. The clinical effect from different studies varied greatly. It may relate to the lack of uniform criteria for the selection of indications, the selection of the donor and the process of transplantation.