TP方案诱导化疗序贯同期放化疗治疗局部晚期鼻咽癌的效果观察

Effect Observation of TP Induction Chemotherapy Combined with Concurrent Radiochemotherapy for Locally Advanced Nasopharyngeal Carcinoma

目的:探讨TP方案诱导化疗序贯同期放化疗治疗局部晚期鼻咽癌的效果。方法:以2011年8月-2014年9月收治的130例局部晚期鼻咽癌患者为研究对象,将130例患者随机等分为试验组与对照组,每组65例。试验组行TP方案诱导化疗序贯同期放化疗治疗,对照组行PF方案诱导化疗序贯同期放化疗治疗。比较两组疗效。结果:试验组有效率为67.69%,对照组有效率为69.23%,两组有效率比较差异无统计学意义(P>0.05)。试验组中位无进展患者平均生存期为(12.4±3.1)个月,对照组为(9.3±1.6)个月,试验组明显长于对照组,差异有统计学意义(P<0.05)。结论:于局部晚期鼻咽癌患者中积极运用TP方案诱导化疗序贯同期放化疗疗法,可延长患者无进展生存时间,值得临床推广应用。

Objective： To investigate the efficacy of TP induction chemotherapy combined with concurrent radiochemotherapy for locally advanced nasopharyngeal carcinoma.Method： 130 cases of admitted patients with locally advanced nasopharyngeal carcinoma from August 2011 to September 2014 were selected as the research objects.They were randomly grouped as experimental group and control group, each consists of 65 eases.The patients in the experimental group were treated with TP induction chemotherapy combined with concurrent radiochemotherapy, whereas, patients in the control group were treated with PF induction chemotherapy combined with concurrent radioehemotherapy.Then, the curative effect was compared between （he two groups.Result： The effective rate of the experimental group was 67.69%, and the effective rate of the control group was 69.23%, the difference between the two groups was not statistically significant（P〉0.05）.The average median progression-free survival time of patients in the experimental group was （12.4 ± 3.1）months, and it was （9.3 ± 1.6）months in the control group, the average median progression-free survival time of the experimental group was longer than that of the control group, the difference was statistically significant（P〈0.05）.Conclusion： The progression-free survival time of the patients can be prolonged by using the TP induction chemotherapy combined with concurrent radiochemotherapy, it is worthy of clinical application.