血清S100B蛋白与血清NSE联合检测在小儿热性惊厥中的应用

Application of Combined Detection of Serum S100B Protein and Serum NSE in Infantile Febrile Convulsion

目的:研究联合检测血清S100B蛋白与血清NSE对小儿热性惊厥导致的脑损伤程度的评估。方法:回顾性分析2013年1月31日-2015年1月31日笔者所在科室86例惊厥患儿血清S100B蛋白与血清NSE的含量,并根据不同惊厥时间分组与正常健康儿童进行相关分析对比。结果:不同惊厥时间组血清S100B蛋白平均浓度(A组除外)与血清NSE平均浓度高于对照组,且惊厥持续时间越长,血清中S100B蛋白浓度与血清NSE浓度越高,差异均有统计学意义(P<0.05)。结论:血清S100B蛋白及血清NSE的测定迅速、准确,其联合检测能够为小儿热性惊厥导致的脑损伤提供临床诊断和治疗的可靠依据。

Objective： To evaluate the degree of infantile febrile convulsion caused by brain damage via combined detection of serum S100B protein and serum NSE.Method： From January 31, 2013 to January 31, 2015 in Ningde Hospital, serum S100B protein and serum NSE content of 86 children with febrile convulsion were retrospectively analyzed, they were divided into different groups according to different seizure time and compared with healthy children. Result： The average concentration of S100B protein（except group A）and serum NSE in the different seizure groups were higher than those in the control group, and the longer the duration of seizures was, the higher the concentration was, the differences were statistically significant（P〈0.05）.Conclusion： Determining the serum S100B protein and serum NSE is quick and accurate, and applying the combined detection to infantile febrile convulsion caused by brain damage can provide a reliable basis for clinical diagnosis and treatment.