微球在磷酸钙骨水泥中的应用

Application of Microspheres in Calcium Phosphate Cement System

磷酸钙骨水泥(CPC)因具有良好的生物活性和生物相容性,目前已成功应用于临床。磷酸钙骨水泥从制备到应用避免了高温烧结的过程,是各类药物和高分子材料的优良载体。本文综述了近年来微球以及各类载药微球与磷酸钙骨水泥相结合的应用,主要从药物缓释、快速降解、形成多孔支架以及改善力学性能这几个方面论述了微球在磷酸钙骨水泥临床应用中的作用。本文通过分析总结微球改善磷酸钙骨水泥性能的原理及方法,为今后进一步改进、制备符合临床使用要求的理想型磷酸钙骨水泥奠定了理论基础。

Calcium phosphate cement（CPC）has been widely used as bone fillers because of its excellent bioactivity and biocompatibility.Meanwhile,CPC is also an attractive candidate for the incorporation of drug or microspheres,because the preparing procedure avoids sintering and heating release.This paper summarizes the clinical applications of microspheres incorporated in CPC from the aspects of sustained drug release,accelerated degradation,porous structure and improved mechanical properties.The paper is aimed to analyze the methods and principles of microspheres loaded CPC,and so as to lay a foundation for the further research of improving and manufacturing the CPC with ideal properties.