摘要
间充质干细胞(MSCs)具有良好的成骨活性。随着细胞和组织工程学的发展,利用MSCs移植来治疗骨损伤已成为新的治疗模式。细胞质膜微囊(Caveolae)是细胞膜内陷形成的烧瓶状质膜微区,主要由胆固醇、鞘磷脂、蛋白质组成。小窝蛋白-1(Caveolin-1)是其主要的蛋白成分。Caveolae是细胞信号的整合器,许多信号分子聚集在此与Caveolin-1结合,调节细胞分化等生命活动。本文将简要综述Caveolae/Caveolin-1在MSCs成骨分化中的作用。
Mesenchymal stem cells（MSCs）have the property of osteogenic induction.As a result,using the property of MSCs to treat the fractures and bone defects has become a new treatment modality with the development of cell and tissue engineering technology.Caveolae is a flask-shaped membrane microdomain in cell membrane,which composed primarily of cholesterol,sphingolipids and proteins.Caveolin-1is one of the main protein component.Caveolae is the integrator of cell signals,and many signal molecules gather here to bind with caveolin-1protein to regulate cell proliferation,differentiation and other life activities.This paper presents a review about Caveolae/Caveolin-1biologic effects on cell differentiation of MSCs.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2016年第4期821-824,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金面上项目资助(81271098)
关键词
小窝蛋白-1
间充质干细胞
成骨分化
caveolin-1
mesenchymal stem cells
osteogenesis differentiation
