芪参扶正胶囊联合TP方案对晚期非小细胞肺癌脾肾亏虚型患者生活质量的影响

The influence of Qishenfuzheng capsule combined with TP in improving the quality of life of patients with advanced non-small cell lung cancer of spleen and kidney deficiency type

目的评价芪参扶正胶囊联合TP方案在提高脾肾亏虚型晚期非小细胞肺癌生活质量方面的有效性、安全性。方法选择寿光市中医医院肿瘤科2012年3月~2015年2月拟TP方案化疗的晚期非小细胞肺癌37例,按1∶1的比例奇偶分组,治疗组18例,对照组19例治疗组采用芪参扶正胶囊加TP化疗方案。对照组采用TP方案化疗。结果治疗组的角色功能、躯体功能、情绪功能领域有明显改善,与治疗前比较,差异有统计学意义（P〈0.05）,治疗组患者中医临床症状评分明显下降,症状改善明显,与对照组比较,差异有统计学意义（P〈0.05）,KPS评分治疗后比对照组明显升高,差异有统计学意义（P〈0.05）,并治疗组在血液毒性及胃肠反应较对照组改善明显。结论芪参扶正胶囊有改善脾肾亏虚型晚期NSCLC患者的生活质量,减轻化疗药物的毒副反应等的综合疗效。

Objective To evaluate the efficacy and safety of Qishenfuzheng capsule combined with TP in improving the quality of life of patients with advanced non-small cell lung cancer of spleen and kidney deficiency type. Methods 37 cases of patients with advanced non-small cell lung cancer proposed TP chemotherapy in Department of Internal Medicine-Oncology of Shouguang Traditional Chinese Medicine Hospital from March 2012 to February 2015 were selected and divided into therapy group（18 cases） and control group（19 cases） with the ratio of 1： 1 parity packets. Patients in therapy group were treated with Qishenfuzheng capsule combined with TP chemotherapy. Patients in control group were treated with TP chemotherapy. Results Compared with before treatment, field of role function, physical function and emotional function of therapy group were significantly improved, the differences were significant（P〈0.05）.TCM clinical symptom score of therapy group was significantly reduced,the difference was significant（P〉0.05）.KPS score after treatment was significantly higher than that of control group, the difference was statistically significant（P〈0.05）.Hematologic toxicity and gastrointestinal reactions of therapy group were much better than those of control group. Conclusion Qishenfuzheng capsule could improve the quality of life of patients with advanced non-small cell lung cancer（NSCLC） of spleen and kidney deficiency type, and could reduce the toxicity of chemotherapy drugs.