热性惊厥儿童血清钠及尿钠的变化及其临床意义的研究

Study on change and its clinical significance of serum sodium and urine sodium of febrile convulsion children

目的探讨热性惊厥儿童血清钠及尿钠的变化及其临床意义。方法选取我院2014年1月~2015年11月入院治疗的88例发热患儿作为研究对象。按照患儿临床表现不同分为研究组与对照组。患儿发热出现惊厥50例作为研究组,患儿发热无惊厥38例作为对照组,另选取我院同期健康体检儿童25例作为正常对照组。通过比较热性惊厥儿童、发热无惊厥儿童及健康儿童的血清钠及尿钠指标,评估上述指标检测结果的临床价值。结果研究组患儿血清钠指标显著低于对照组及正常对照组,研究组患儿的尿钠指标显著高于对照组及正常对照组,差异有统计学意义（P〈0.05）。研究组患儿中发生热性惊厥次数≥2次患儿较热性惊厥次数〈2次患儿血清钠水平低,差异有统计学意义（P〈0.05）。惊厥次数不同患儿,≥2次惊厥患儿其低钠血症发生率高于〈2次惊厥患儿,差异有统计学意义（P〈0.05）。结论临床监测热性惊厥患儿血清钠及尿钠水平的变化,指导临床治疗药物的选择,维持患儿机体电解质平衡,减少反复惊厥次数,防止脑部损伤及后遗症给患儿带来的危害。

Objective To explore the change and its clinical significance of serum sodium and urine sodium of febrile convulsion children. Methods 88 cases of feverish children cured in our hospital from January 2014 to November 2015 were selected as the study objects. According to the different clinical manifestations of children, they were divided into control group and study group. 50 cases of febrile children with convulsions were selected as study group, and 38 cases of febrile children without convulsions were selected as control group, and another 25 cases of healthy children in our hospital were selected as the normal control group. By comparing serum sodium and urine sodium indicators of febrile children with convulsions, febrile children without convulsions and healthy children, clinical value of test results of the above indicators was assessed. Results Serum sodium indicator of study group was significantly lower than that of control group and normal control group. Urine sodium indicator of study group was significantly higher control group and normal control group. And the differences were statistically significant（P 〈 0.05）. Serum sodium level of children with febrile seizure frequency ≥2 is lower than that of children with febrile seizure frequency 〈 2 in study group, and the difference was statistically significant （P 〈 0.05）. Incidence of hyponatremia of children with febrile seizure frequency ≥ 2 is higher than that of children with febrile seizure frequency 〈 2, and the difference was statistically significant （P 〈 0.05）. Conclusion Clinical monitoring of changes of serum sodium and urine sodium levels in children with febrile convulsion can guide the selection of clinical therapeutic drugs, reduce the number of recurrent seizures, prevent brain damage, and reduce the harm to the children caused by sequelae.