人巨细胞病毒感染和围着床期子宫内膜容受性的相关性分析

The study on the effects of Human Cytomegalovirus infection on endometrial receptivity during peri-implantation period

目的：分析人巨细胞病毒感染与围着床期子宫内膜容受性关系,为着床不利因素提供参考。方法：选取我院孕龄期妇女为研究对象,在月经20-24d子宫内膜诊刮,测定孕激素水平,检测人巨细胞病毒感染情况,分为活动性感染组、未感染组和既往感染组,定量分析子宫内膜上性激素受体以及整合素β3亚单位变化,并分析临床妊娠率。结果：三组妇女孕激素水平、子宫内膜厚度无明显差异（P〉0.05）,子宫内膜标本HE染色均未出现细胞形态学改变、淋巴细胞侵润炎症反应。三组患者雌激素和雄激素受体无明显差异（P〉0.05）,活动性感染组整合素β3表达（1.6±0.5）显著低于既往感染组（2.8±0.3）和未感染组（2.9±0.4）（P〈0.05）,既往感染组组整合素β3表达与未感染差异不明显（P〉0.05）。未感染组（68.7%）和既往感染组患者临床妊娠率（61.5%）显著高于活动性感染组（31.8%）（P〈0.05）。结论：人巨细胞病毒感染引起整合素β3亚单位下降,对性激素受体无明显影响,影响子宫内膜容受性变化。

Objective：To analyze the study on the effects of Human Cytomegalovirus infection on endometrial receptivity during periimplantation period,and analyze reference implantation for unfavorable factors.Methods：Gestational age of implantation endometrium specimens in hospital from May 2014 to December 2015 were selected,Endometrial curettage was did in 20-24d,progesterone levels are measured,patients divided intoactive infection group,uninfected group and past infection group according to HCMV infection,hormone receptor and integrinβ3subunit on endometrial changes were quantitative analysis.Results：There were no significant differences in the level of progesterone and endometrial thickness between the three groups（P〈0.05）.The changes of cell morphology,lymphocyte infiltration and inflammatory reaction were not found in the endometrial specimens HE staining.Three groups of patients with estrogen and androgen receptor（AR）was not significant difference（P〈0.05）,the activity of infected group of integrin 3expression（1.6 ＋ 0.5）was significantly lower than that of previous infection group（2.8 ＋ 0.3）and non infection group（2.9 ＋ 0.4）（P〈0.05）,previous infection group and non infected group of integrin 3expression were no significant difference（P〈0.05）.The clinical pregnancy rate（61.5%）was significantly higher in the uninfected group（68.7%）than in the active group（31.8%）（P〈0.05）.Conclusion：HCMV infection integrinβ3subunit decreased receptor had no effect on sex hormones,affect endometrial receptivity changes.