四磨汤口服液联合双歧杆菌三联活菌胶囊治疗小儿功能性消化不良疗效观察

Clinical efficacy observation on pediatric functional dyspepsia treated with Simotang oral liquid and Bifico

目的观察四磨汤口服液联合双歧杆菌三联活菌胶囊治疗小儿功能性消化不良的疗效。方法2013年9月至2015年11月河南省西华县人民医院儿科收治功能性消化不良患儿114例,随机分为对照组和观察组各57例。对照组给予四磨汤口服液治疗,观察组在对照组基础上给予双歧杆菌三联活菌胶囊治疗,疗程5d。观察两组治疗效果及食欲不振、腹胀、恶心呕吐及便溏不消化等症状变化;患儿血清一氧化氮、胃泌素、血浆胃动素水平变化。结果观察组疗效优于对照组,差异有统计学意义(P<0.05);观察组食欲不振、腹胀、恶心呕吐、便溏不消化评分下降程度高于对照组,差异有统计学意义(P<0.05);观察组胃泌素、胃动素水平升高及一氧化氮降低程度优于对照组,差异有统计学意义(P<0.05)。结论四磨汤口服液联合双歧杆菌三联活菌胶囊治疗小儿功能性消化不良可有效提高临床疗效,改善症状,且安全性良好,值得临床推广。

Objective To observe the clinical effect of Simotang oral liquid and Bifico on pediatric functional dyspepsia.Methods According to the random number table,114 cases of pediatric functional dyspepsia were randomly divided into the control group and the observation group,each groups with 57cases;the control group was treated with Simotang oral liquid,while observation group with Bifico on the base of control group;the effects of two groups were compared.Results After treatment,the effect of observation group was significantly better than control group（P〈0.05）;the score decrease of poor appetite,abdominal distension,nausea and vomiting and loose stool indigestion was greater in the observation group than that of control group（P〈0.05）;the level increase of gastrin and motilin in the observation group was better than that of control group;the level decrease of nitrogen monoxidum in the observation group was better than that of control group（P〈0.05）.Conclusion In treating pediatric functional dyspepsia,combined therapy of Simotang oral liquid and Bifico can increase curative effect and improve symptom and is safe,so it is worthy of clinical promotion.