利巴韦林联合柴桂退热颗粒治疗儿童上呼吸道感染疗效观察

Clinical value of ribavirin combined with Chaigui antifebrile granules in treatment of children with upper respiratory tract infection

目的观察利巴韦林联合柴桂退热颗粒治疗上呼吸道感染的疗效。方法 2013年10月至2015年10月深圳市福田区妇幼保健院儿科收治上呼吸道感染患儿180例,随机分为中西医结合组、西药治疗组和中药治疗组各60例。中西医结合组采用利巴韦林联合柴桂退热颗粒治疗,西药治疗组采用利巴韦林注射液治疗,中药治疗组采用柴桂退热颗粒治疗。3组患儿疗程均为7d,观察各组疗效、退热时间、止涕时间、咽部红肿消退时间、痊愈时间及不良反应情况。结果中西医结合组患儿退热时间、止涕时间及痊愈时间均较西药治疗组和中药治疗组明显缩短,差异有统计学意义(P<0.05);中西医结合组治疗总有效率为98.3%(59/60),显著高于中药治疗组85.0%(51/60),差异有统计学意义(P<0.017)。结论利巴韦林联合柴桂退热颗粒治疗小儿上呼吸道感染疗效确切,退热、止涕及痊愈时间明显较单药治疗缩短,推荐临床推广应用。

Objective To evaluate the effect of ribavirin combined with Chaigui antifebrile granules in the treatment of children with upper respiratory tract infection.Methods Totally 180 children diagnosed with upper respiratory tract infection in our hospital from October 2013 to October 2015 were involved in this research.They were randomly divided into three groups：60children in combination therapy group received ribavirin combined with Chaigui antifebrile granules,60 children in western medicine group received ribavirin,and 60 children in Chinese medicine treatment group received Chaigui antifebrile granules.The clinical efficacy was compared in three groups.Results The defervescence time,the time of stopping sniveling and the cure time of combination therapy group were obviously shorter than those in western medicine group and Chinese medicine treatment group（P〈0.05）.The total effective rate was significantly higher in the combination group（98.3%,59/60）than in Chinese medicine treatment group（85.0%,51/60）（P〈0.017）.Conclusion Ribavirin combined with Chaigui antifebrile granules is effective in treatment of children with upper respiratory tract infection,and defervescence time,the time of stopping sniveling and the cure time is obviously shorter than medication alone,which is worth being recommended for clinical popularization and application.