冠心病患者NT-proBNP水平与心力衰竭的程度相关

The NT-ProBNP Level is Associate with Severity of Heart Failure in Coronary Heart Disease Patient

目的探讨血浆N-末端脑钠肽前体(NT-proBNP)水平与冠状动脉病患者心力衰竭程度的关系。方法2015年因冠心病在我院就诊且行冠脉造影患者153例入选本研究,另选同期入院非冠心病患者20例为对照组。测定各患者血浆NT-proBNP水平和左室射血分数(LVEF)。结果血浆NT-proBNP水平对照组明显低于各冠脉病变组(P<0.01)。血浆NT-proBNP水平与LVEF(r=-0.170,P<0.05)呈负相关,多元逐步回归分析显示血浆NT-proBNP水平对冠心病后心力衰竭有独立的预测价值。结论血浆NT-proBNP水平可以反映冠心病患者心力衰竭的严重程度,患者血浆NT-proBNP水平有助于指导判断预后。

Objective To determine the relationship between the N-terminal prohormone of brain natriureticpeptide（ NT -proBNP） level and the degree of heart failure in patients with coronary artery disease. MethodsDuring 2015,153 cases with coronary artery diseases with proof of coronary angiography in our hospitalwere included in this study. 20 healthy people without coronary disease were used as control. The plasma N T -proBNP levels and left ventricular ejection fraction （LVEF ） were measured in all patients. Results Plasma levelof NT-proBNP in the control group were significantly lower than those in the coronary artery disease group （ P 〈0. 01） . The plasma NT-proBNP levels were negatively correlated with LVEF （ r = -0. 170 ,P 〈0. 05） . Multiplestepwise regression analysis showed that plasma NT-proBNP levels related to the severity of heart failure whichmay serve as independent predictive value. Conclusion Plasma NT-proBNP level can reflect the severity of heartfailure in patients with coronary heart disease, which may serve as a prediction for the prognosis.