血清C肽水平与2型糖尿病患者不同并发症的相关性研究

Correlations among serum C peptide level and different complications in patients with type 2 diabetes mellitus

目的:探讨血清C肽水平与2型糖尿病患者不同并发症发生之间的关系。方法:选择53例2型糖尿病(T2DM)患者,记录其性别、年龄、体重指数(body mass index,BMI)、病程和合并疾病等相关信息。收集患者空腹血清,采用生化分析仪检测其血糖、血脂和肝功能等指标。采用t检验和卡方检验等方法探讨不同并发症之间的临床特征,采用Spearman相关分析的方法探讨C肽与T2DM患者不同并发症之间的相关性。结果:糖尿病酮症酸中毒T2DM患者,年龄明显低于未合并患者(52±2.92 vs 60.93±1.52),空腹C肽水平则明显高于未合并患者(2.2±0.66 vs 1.04±0.13)。两组患者的C肽≥1.1和C肽<1.1,在合并不同并发症的概率上差异无统计学意义。Spearman相关分析发现,C肽水平与T2DM患者糖尿病酮症酸中毒呈现正相关的关系(r=0.448,P=0.010),与T2DM患者糖尿病视网膜病变则呈现负相关的关系(r=-0.393,P=0.026)。结论:C肽在T2DM患者合并酮症酸中毒的发生中起着重要作用。

Objective To investigate correlations among serum C peptide level and different complications in patients with type2 diabetes mellitus. Methods： 53 patients with T2 DM were selected, and their gender, age, BMI, course of disease, and combineddiseases were recorded. The serum of these patients was collected, and the indexes of blood glucose, blood lipid and liver functionwere detected by biochemical analyzer. T test and chi square test were used to investigate the clinical characteristics of different complications, and the correlations among C peptide level and different complications was analyzed by Spearman correlation analysis. Results：Age was significantly lower in the patients with diabetic ketoacidosis than those without diabetic ketoacidosis （ 52 ± 2.92 vs 60.93± 1.52 ） , while the fasting C peptide level was significantly higher （ 2.2 ± 0.66 vs 1.04±0.13）. There was no significant difference inthe probability of different complications between C peptide ≥1.1 and C peptide〈1.1. The Spearman correlation analysis found that the C peptide level and diabetic ketoacidosis showed a positive correlation （r = 0. 448, P = 0. 010） , and the C peptide level and diabeticretinopathyshowed a negative correlation （ r = - 0 . 393, P = 0.026）. Conclusions ： C peptide plays an important role in the occurrenceof ketoacidosis in the T2 DM patients.