不同剂量美托洛尔在慢性心力衰竭中的应用

Application of different doses of mctoprolol in patients with chronic heart failure

目的观察及比较不同剂量美托洛尔对心功能不全患者心功能状态的影响程度。方法收集2013年1月至2014年9月在佛山市第二人民医院住院的心功能Ⅱ～Ⅳ级的慢性充血性心力衰竭患者220例。根据每日应用美托洛尔的总量不同为分组标准，其中A组68例（100—200mg／d），B组97例（75—100mg／d），C组55例（≤75mg／d）。然后将3组患者治疗前、后的心功能状态相关指标分别进行统计与比较。结果A、B组治疗后6个月及1年心功能状态相关指标均优于c组．其中A组在改善心功能方面明显优于C组，差异具有统计学意义（P〈0．05）。结论中、高剂量美托洛尔治疗慢性心力衰竭，长期使用利大于弊，临床上应用尽可能使其剂量接近或达到目标剂量，使患者长期获益。

Objectives To investigate the efficacy of metoprolol in patients with chronic heart failure. Methods A total of 220 patients with chronic heart failure who received treatment in The Second People＇s Hospital of Foshan from January 2013 to September 2014 were randomly selected for this study. These patients were divided into three groups according to the amount of metoprolol they received daily： group A [68 cases, （100-200） mg/day], group B [ 68 cases, （75-100） rag/day ] and group C （68 cases, 〈75 mg/day）. Cardiac function indexes of the three groups before and after treatment were statistically analyzed and compared. Results Related parameters of cardiac function in groups A and B after treatment for 6 months and 1 year were better than those in group C （P〈0.05）. Related parameters of improving cardiac function in A group were significantly better than those in C group （P〈0.05）. Conclusions Metoprolol therapy is highly effective for patients with chronic heart failure. It not only significantly improves heart functions and quality of life in these patients, but also has high safety and reliability. Therefore, target dose is recommended in the clinical treatment for chronic heart failure to benefit patients in a long term.