孟鲁司特钠治疗小儿反复发作过敏性紫癜的临床研究

Clinical study on Montelukast sodium treatment among children with recurrent Henoch-Schonlein purpura

目的探讨孟鲁司特钠治疗小儿反复发作过敏性紫癜(HSP)的临床效果。方法将120例反复发作HSP患儿随机分为两组,各60例。两组患儿均给予抗感染、抗过敏、卧床休息等基础治疗措施,观察组在此基础上加用孟鲁司特钠片治疗,比较两组临床效果。结果治疗后,观察组患儿尿免疫球蛋白G(Ig G)、微量白蛋白(ALB)、转铁蛋白(TRF)、β2微球蛋白(β2MG)水平均低于对照组(P<0.01),血清白细胞介素(IL-6)、白细胞介素-8(IL-8)水平均低于对照组(P<0.01);观察组治疗总有效率为95.00%,高于对照组的80.00%(P<0.05);治疗12个月后,观察组复发率为11.67%,低于对照组的26.67%(P<0.05)。结论孟鲁司特钠结合常规疗法治疗小儿反复发作HSP效果显著,可提高治疗有效率,降低复发率。

Objective To investigate the clinical effect of Montelukast sodium treatment among children with recurrent Henoch-Schonlein purpura. Methods One hundred and twenty cases of recurrent Henoch-Schonlein purpura were randomly divided into observation group and control group,60 cases in each group. Two groups were given treatment of antiinfection,antiallergy,rest and other basic treatment measures,the observation group was added with Montelukast sodium treatment. Results After treatment,urine Ig G,ALB,TRF,β2MG,serum IL-6,IL-8 of observation group were significantly lower than those of control group（ P〈0. 01）,and the efficiency rate 95. 00% of observation group was higher than that 80. 00% of control group（ P〈0. 05）. Recurrence rate after 12 month of observation group（ 11. 67%） was significantly lower than that of children in the control group（ 26. 67%）（ P〈0. 05）. Conclusion Montelukast combined with conventional therapy on recurrent Henoch-Schonlein purpura can improve clinical outcomes,reduce the recurrence rate after treatment.