首发广泛性焦虑障碍患者外周血炎性细胞因子与执行功能的相关性

The correlation between peripheral inflammatory cytokines and executive functions in patients with first-onset generalized anxiety disorder

目的探讨首发广泛性焦虑障碍患者外周血炎性细胞因子与执行功能的关系。方法对48名首发广泛性焦虑障碍患者(研究组)及48名正常人(对照组)应用广泛性焦虑障碍量表(GAD-7)评估焦虑水平,剑桥神经心理自动化成套测试软件(CANTAB)中内外空间成套转换测验(IED)测定执行功能,夹心法酶联免疫吸附法(ELISA)测定外周血IL-1α、IL-6、IL-10浓度。结果研究组GAD-7评分高于对照组(P<0.05)。研究组IED的总错误数、外维转换错误数、完成测试数高于对照组(P<0.05)。研究组外周血IL-1α、IL-6水平高于对照组(P<0.05)。在研究组中,IED的外维转换错误数与外周血IL-1α水平呈正相关(P<0.05),外维转换前错误数、外维转换错误数与外周血IL-6水平呈正相关(P<0.05)。结论首发广泛性焦虑障碍患者存在炎性细胞因子和执行功能异常,且两者之间存在相关性。

Objective To explore the correlation between peripheral inflammatory cytokines and executive functions in patients with first-onset generalized anxiety disorder. Method A total of 48 patients with first-onset generalized anxiety disorder in study group and 48 healthy subjects in control group were selected and assessed with Generalized Anxiety Disorder Scale （GAD-7） for level of anxiety, Intra/Extradimensional Set Shift （IED） in Cambridge Neuropsychological Test Automatic Battery （CANTAB） for executive functions and Enzyme-Linked Immunosorbent Assay （ELISA）for levels of IL-1 a, IL-6, IL-10. Results The GAD-7 score of study group was higher than that of control group （ P 〈 0. 05 ）. The numbers of total errors, extradimensional shift errors and completed tests of IED in study group were all significantly higher than those in control group（ P 〈 0.05 ）. The levels of IL-1a and IL-6 in study group were all significantly higher than those in control group（ P 〈 0.05 ）. In study group, the level of IL-1a was positively correlated to the number of extradimensional shift errors in IED （P 〈 0.05 ） , and the level of IL-6 was positively correlated to the numbers of ex-extradimensional shift errors and extradimensional shift errors in IED（ P 〈 0.05 ）. Conclusion Peripheral inflammatory cytokines and executive functions are abnormal in patients with first- onset generalized anxiety disorder and they are correlated with each other.