胆汁淤积性肝病诊断相关生化指标的探讨

Biochemical parameters in diagnosis of cholestatic liver disease

尽管近年来国内外相继发布有关"胆汁淤积性肝病"诊疗指南及专家共识,但关于胆汁淤积诊断的生化标准还存在很多问题,比如不同原因引起的胆汁淤积有各自的诊断标准,差异很大。这给临床医生带来很大困扰,也不利于相关科研的进行。就胆汁淤积相关的常见指标进行了分析,并指出了当前诊断中存在的问题。建议相关组织进一步深入讨论并规范关于胆汁淤积诊断的生化指标,为深入开展胆汁淤积的临床和科研工作提供更可靠的依据。

Although guidelines and expert consensuses have been published on the diagnosis and treatment of cholestatic liver disease recently in China and the rest of the world,many problems still exist in the biochemical standard for the diagnosis of cholestasis; for example,there are substantially different diagnostic criteria for cholestasis of various causes. This brings confusion to clinical doctors and is not good for research. This article analyzes common parameters in cholestasis and points out the problems in diagnosis. It is recommended to organize in- depth discussions and set standard for the diagnosis of cholestasis,in order to provide a more reliable basis for clinical research on cholestasis.