摘要
目前治疗手段难以彻底治愈慢性乙型肝炎(CHB)。自然杀伤细胞(NK细胞)是天然免疫的一个重要组成部分,在机体免疫监视和早期抗感染免疫过程中起重要作用。白细胞介素10(IL-10)是一种多功能负性调节因子,参与免疫细胞和炎症细胞等的生物调节。介绍了IL-10和NK细胞的特点及功能,CHB与IL-10和NK细胞的关系,以及IL-10和NK细胞在CHB治疗中的意义,认为在CHB中IL-10可能发挥了负性调控NK细胞功能的作用,但是能否通过阻断IL-10对NK细胞的调控作用提高NK细胞的抗病毒功能,同时避免NK细胞激活造成的肝脏免疫病理,仍有待进一步研究。
At present,it is very difficult to cure chronic hepatitis B（ CHB） with current therapeutic methods. Natural killer（ NK） cells are an important part of innate immunity and play an important role in immune surveillance and early anti- infectious immune process. Interleukin- 10（ IL- 10） is a multifunctional negative regulatory factor and is involved in the biological regulation of immune cells and inflammatory cells. This article introduces the features and functions of IL- 10 and NK cells,the association of CHB with IL- 10 and NK cells,and the value of IL- 10 and NK cells in the treatment of CHB,and points out that in CHB,IL- 10 exerts a negative regulatory effect on NK cells. Further investigations are needed to confirm whether the antiviral function of NK cells can be enhanced through blocking the regulatory effect of IL- 10 on NK cells,and whether liver immunopathology induced by activation of NK cells can be avoided at the same time.
出处
《临床肝胆病杂志》
CAS
2016年第8期1600-1603,共4页
Journal of Clinical Hepatology
基金
国家重大科技专项-艾滋病和病毒性肝炎等重大传染病防治专项资助项目(2014ZX10002002-002)
