α,β-不饱和酮与三氟甲基酮的Aldol反应研究

Study of the Aldol Reactions of α,β-Unsaturated Ketones with Trifluoromethyl Ketones

通过对辅助酸、溶剂以及反应物的用量变化等诸因素的考察,确定了最优的反应条件。然后,实现了不同结构的α,β-不饱和酮与三氟甲基酮的Aldol反应,以最高88%的产率获得了含有三氟甲基的β-羟基羰基化合物。

Through the study of the factors of acid, solvent and the amount of reactants, we obtained the optimal reaction condition. Then, aldol reaction of the different structure of α,β-unsaturated ketones with trifluoromethyl ketones, affording trifluoromethylated β-hydroxycarbonyl aldol products in high yields （up to 88 % yield）.