华坪县2013-2015年健康人群麻疹抗体水平监测结果分析

The Measles Antibody Level Monitoring of Healthy Population in Huaping,2013-2015

目的了解华坪县健康人群麻疹抗体水平,发现工作薄弱地区和免疫空白人群,为实现消除麻疹的目标提供科学依据。方法采用分层抽样方法对华坪县8个乡镇不同年龄段健康人群开展麻疹抗体监测,采用间接酶联免疫吸附试验（ELISA间接法）检测血清麻疹Ig G抗体。结果 2013-2015年共检测1 106人,麻疹抗体总阳性率96.47%。其中,阳性率较低的是2014年（93.13%）,人群是8～17月龄组（89.22%）。尚有新庄乡（89.92%）、船房乡（93.98%）,通达乡（94.86%）3个乡镇麻疹抗体阳性低于95%。有免疫史者人群阳性率较无免疫史者高（χ^2=5.1830,P=0.023）,男女性别间无差异。结论华坪县人群麻疹免疫效果较好,但存在免疫薄弱地区和免疫空白人群,应结合该监测结果,加强重点乡镇麻疹疫苗两剂次接种工作和抗体阴性人群的重新免疫接种。

Objective To investigate the level of measles antibody in healthy people in Huaping county.,explore the population without vaccination and weaknesses in work,and provide the evidence for measles control and prevention. Methods The healthy people with different age were sampled from 8 villages and towns in Huaping by cluster sample methods,the MV- Ig G of measles tested by enzyme linked immunosorbent assay（ indirect ELISA）. Results A total of 1 106 participants were sampled in the county during 2013 to 2015. The antibody rate was 96. 47%. The lowest positive rate was age 8- 17months（ 89. 22%） and the year of 2014（ 93. 13%）. The measles antibody positive was less than 95% in Xinzhuang（ 89. 92%）,Chuanfang（ 93. 98%） and Tongda（ 94. 86%）. The immune positive rate in historic immunization people was higher than others（ χ^2= 5. 183 0,P = 0. 023）,but there was no difference between male and female. Conclusion The immunization effect of measles is satisfactory in Huaping county. However,there are still immune blank group and weakness area. The work of two doses of measles vaccine should be strengthened in the key towns and re- vaccination should work in antibody negative people.