社区人群中H型高血压与颈股脉搏波传导速度的关系

Relationship between H-type hypertension and carotid-femoral PWV in community residents

目的探讨H型高血压与颈股脉搏波传导速度（carotid-femoral PWV,cfPWV）所代表的动脉硬化之间的关系。方法纳入北京市石景山区首钢社区参加健康调查的人群1497例,根据同型半胱氨酸水平分为H型高血压组499例和非H型高血压组998例。检测身高、体质量、体质量指数、血压、TC、TG、LDL-C、HDL-C、空腹血糖、同型半胱氨酸、肌酐等指标,分析H型高血压对cfPWV的影响。结果 H型高血压组cfPWV较非H型高血压组显著升高,差异有统计学意义[（12.72±3.08）m/s vs（10.88±2.53）m/s,P〈0.01]。多元逐步线性回归分析显示,H型高血压与cfPWV呈正相关（偏回归系数=0.474,95%CI：0.177-0.771,P=0.002）。结论 H型高血压是动脉硬化的独立危险因素。在社区高血压人群中,H型高血压并未显示与动脉硬化相关,提示高血压对动脉硬化起到了重要作用,同型半胱氨酸升高可能在高血压对动脉硬化的进程中起到了协同作用。对于H型高血压的预防和治疗更应该引起重视。

Objective To study the relationship between H-type hypertension and carotid-femoral PWV（cfPWV）in community residents.Methods A total of 1497 residents from Community of Beijing Shougang Co.,Lited were divided into H-type hypertension group（n=499）and non Htype hypertension group（n=998）according to their serum homocyssteine（Hcy）level.Their body hight,BM,BMI,BP,serum levels of TC,TG,LDL-C,HDL-C,fast blood glucose,Hcy and creatinine were meaured.Effect of H-type hypertension on cfPMV was analyzed.Results The cfPWV was significantly faster in H-type hypertension group than in non H-type hypertension group（12.72±3.08 m/s vs 10.88±2.53 m/s,P〈0.01）.Multivariate linear regression analysis revealed that H-type hypertension was positively related with cfPWV（B=0.474,95%CI：0.177-0.771,P=0.002）.Conclusion H-type hypertension is an independent risk factor for arterosclerosis.However,H-type hypertension is not associated with arterosclerosis in community residents,inedicating that hypertension plays an important role in arterosclerosis and elevated Hcy level plays a synergistic role in hypertension-induced arterosclerosis.Importance should thus be attached to the prevention and diagnosis of H-type hypertension.