嗜酸性胃肠道疾病的研究进展

Research progress of eosinophilic gastrointestinal disease

嗜酸性胃肠道疾病(eosinophilic gastrointestinal disease,EGID)是一种以嗜酸性粒细胞(eosinophil granulocyte,Eo S)不同程度浸润胃肠道为特征的消化道疾病。目前,EGID病因及发病机制尚不清楚,Eo S局部浸润及脱颗粒和Th2反应可能是其发病基础。临床表现依据Eo S浸润深度、部位及范围表现多样,内镜下肉眼所见缺乏特异性,临床医师对该病认识不足,容易造成误诊或漏诊。除糖皮质激素是EGID的主要治疗药物外,近年来,白三烯抑制剂、肥大细胞稳定剂等免疫靶向药物有一定疗效。

Eosinophilic gastrointestinal disease（ EGID） is a digestive disease,which is characteristic of different levels of eosinophils granulocyte（ Eo S） infiltration of the gastrointestinal tract, including eosinophilic esophagitis（ Eo E）,eosinophilic gastroenteritis（ EG） and eosinophilic colitis（ EC）. At present,the etiology and pathogenesis of EGID are unclear,Eo S local infiltration,degranulation and Th2 response may be the foundation of EGID onset. According to the Eo S infiltrating the scope and depth of the gastrointestinal tract,clinical manifestations place show diversity,microscopically visible to the naked eye can see lack of specificity,and clinicians to insufficient understanding of the disease,easy misdiagnosis or missed diagnosis. Glucocorticoids are the main drugs,curative effect is distinct. In recent years,leukotriene inhibitors,mast cell stabilizer,immune pathway targeted drugs have certain curative effect.