健康体检人群空腹血糖、糖化血红蛋白联合检测的应用研究

Analysis of Combined Measurements of Fasting Blood Glucose and Glycosylated Hemoglobin in Physical Examination

目的分析空腹血糖、糖化血红蛋白联合检测在健康体检中的应用价值。方法选择北京市海淀医院437名健康体检者作为研究对象,分别检测其空腹血糖、糖化血红蛋白水平,并对二者的相关性进行分析。结果 437名研究对象中,糖化血红蛋白〈5.5%者139例,5.5%-6.5%者257例,〉6.5%者41例。糖化血红蛋白〉6.5%者的空腹血糖水平均明显高于〈5.5%、5.5%-6.5%者（P〈0.01）。相关分析显示,437名体检者的糖化血红蛋白水平与空腹血糖水平之间呈正相关（P〈0.01）。结论健康人群空腹血糖、糖化血红蛋白联合检测对糖尿病的筛查具有重要价值,适合在健康人群体检中推广。

Objective To investigate the application value of combined measurements of fasting blood glucose （FBG） and glycosylated hemoglobin A1 c （HbA1 c） in physical examination. Methods Both the blood level and correlation of FBG and HbAlc were analyzed from a total of 437 subjects who had undergone physical examination in Beijing Haidian Hospital. Results Out of 437 subjects of the study, 139 subjects had HbAlc levels of 〈 5.5% ,257 subjects had HbAlc levels of 5.5% to 6.5% ,and 41 subjects had HbAlc levels 〉6.5% （P 〈0.01 ）. All the subjects with HbAlc levels of 〉 6.5% had significantly higher levels of FBG than those with HbA1 c levels of 〈 5.5 % and 5.5 % to 6.5% （P 〈 0.01 ）. Correlation analysis showed that there was a positive correlation between HbAlc levels and FBG levels among the 437 subjects （P 〈0.01 ）. Conclusion Combined measurements of FBG and HbA1 c had significant value in diabetes screening and were suitable for promoting in physical examination among healthy population.