血清细胞因子对术后患者状态评估中的应用研究进展

Research Progress of Serum Cytokines in Evaluating the Condition of Postoperative Patients

细胞因子(cytokine)是由机体各种细胞所产生的生物活性蛋白,调节机体的各种生理和病理状态;一些细胞因子还通过直接或间接的途径参与了机体的免疫应答。各种生理和病理因素均可诱导机体特定细胞因子的产生,当这些细胞因子进入血循环或浆膜腔液等,可以采用免疫学方法对其进行定量检测。经历创伤大的手术使机体处于应激状态,如果出现各种并发症或术后的复杂状态,一些特定的细胞因子产生显著改变。因此,检测体内细胞因子的浓度可以较直观的反映出机体病理生理的变化。本文综述了国内外对细胞因子在评估术后患者状态中应用的最新研究进展。

Cytokines are bioactive proteins produced by many different cells to regulate various physiological and pathologicalevents.Some cytokines involve in the body＇s immune response by direct or indirect ways.Meanwhile a variety of physiological and pathological factors can induce the production of specific cytokines.And when these cytokines enter into blood circulation or serous fluid,researchers can use immunological method for quantitative detection.In the event of a traumatic surgery,the body is in a state of stress.When any postoperative complications or complex states occurred at the time,some specific cytokines could have a significant change.The concentration of cytokines closely correlates to the immune responses,which reflect the pathophysiological changes of the body.This paper summarizes the latest research progress of cytokines in evaluating the conditions of postoperative patients.