甘遂醋制前后对癌性腹水模型大鼠泻水逐饮功效比较

Comparative study on expelling water retention with drastic purgative of crude and vinegar stir-baked Kansui Radix in cancerous ascites rats

目的考察甘遂醋制前后对癌性腹水模型大鼠泻水逐饮功效的差异。方法以癌性腹水模型大鼠为研究对象,呋塞米为阳性药,分组连续7 d ig生、醋甘遂粉末及醇提加水提物,考察其对大鼠尿量,腹水量,尿钠、钾、氯离子水平,尿液p H值,肾素-血管紧张素II-醛固酮系统(RAAS),抗利尿激素(ADH)水平的影响。结果与模型组比较,各给药组大鼠尿量显著增加(P<0.05、0.01);腹水量,尿钠、钾、氯离子水平,尿液p H值显著减少(P<0.01);血清肾素(PRA)、血管紧张素II(Ang II)、醛固酮(ALD)、ADH水平显著降低(P<0.05、0.01)。其中生、醋甘遂粉末给药功效最为显著,且两组间无显著性差异。结论生、醋甘遂均具显著的泻水逐饮功效,对癌性腹水模型大鼠有良好的症状改善作用。

Objective To compare the function of expelling water retention with drastic purgative of crude and vinegar stir-baked Kansui Radix in cancerous ascites model rats. Methods Furosemide was taken as positive control drug, and the cancerous ascites model rats were respectively orally administered with powder of crude and vinegar stir-baked Kansui Radix and their alcohol and water extract for 7 d. The amounts of urine and ascites, the levels of urinary sodium, potassium, chlorideion, and p H value, and the contents of PRA, Ang II, ALD, and ADH in serum were investigated. Results Compared with model group, the amount of urine of each medication administration group significantly increased（P 〈 0.05, 0.01）, the amount of ascites, the levels of urinary sodium,potassium, chlorideion, and p H value（P 〈 0.01）, and the contents of PRA, Ang II, ALD, and ADH in serum all showed a significant decrease（P 〈 0.05, 0.01）. Among them, the groups which were administered with powder of crude and vinegar stir-baked Kansui Radix were the most significant, and there was no significant difference between the two groups. Conclusion The powders of crude and vinegar stir-baked Kansui Radix have a remarkable effect on expelling water retention with drastic purgative, and they could improve the symptom of cancerous ascites model rats.