抗神经元抗体对神经系统副肿瘤综合征诊断的意义

Significance of the detection of anti-neuronal antibodies in the diagnosis of paraneoplastic syndrome of nervous system

目的探讨抗神经元抗体谱对神经系统副肿瘤综合征(paraneoplastic syndrome of nervous system,PNSNS)临床诊断的价值。方法本研究采用神经元抗原谱抗体Ig G试剂盒(欧蒙医学实验诊断股份公司)对68份血清样本的抗Hu抗体、抗Yo抗体、抗Ri抗体、抗Ma2/ta抗体、抗CV2抗体、抗Amp抗体进行检测。结果 48例PNSNS中阳性6例(6/48,12.5%),其中A组中枢神经脱髓鞘病阳性率为23.5%(4/17)、B组运动神经元病阳性率为0%(0/11)、C组格林巴利综合征阳性率为10.0%(2/20);健康体检者阳性率为0(0/20)。PNSNS疾病组中中枢神经脱髓鞘病与格林巴利综合征疾病的阳性率和健康对照组相比,差异无统计学意义(P>0.05),但PNSNS疾病组抗神经元抗体的阳性率有高于健康对照组的趋势。结论血清中神经元特异性抗体谱的测定有助于神经系统副肿瘤性综合征中的一些疾病的诊断。

Objective To evaluate the significance of the detection of anti-neuronal antibodies in the early diagnosis of paraneoplastic syndrome（ PNS） of nervous system（ PNSNS）. Methods We detected anti-Hu,anti-Yo,anti-Ri,anti-Ma2 / ta,anti-CV2,antiAmphiphysin antibodies of 68 sera by neuronal antigen spectrum of Ig G antibody kit（ amount medical laboratory diagnostics ag）; Results Of the 48 PNS samples,6（ 6 /48,12. 5%） were positive for anti-neuronal autoantibodies,among which,4（ 23. 5%） positive samples were from Group A（ demyelinating diseases）,2（ 10. 0%） positive samples were from Group C（ Guillain-Barre syndrome）; samples from Group B（ motor neuron diseasse） and D（ Healthy control） were all negative. There was a trend of higher ratio of anti-neuronal antibodies positive rate in PNSNS group than healthy control group,although the data failed to reach a statistical significance. Conclusion The detection of anti-neuronal antibodies might be a credible method in the early diagnosis of PNSNS.