期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

表观遗传学调控Th细胞分化发育的研究进展 被引量：4

The research progress of epigenetic regulation of T helper cell differentiation
下载PDF
导出
摘要 CD4^+辅助性T细胞(Th细胞)在抗原刺激与机体微环境调控下分化发育为不同的细胞亚群以对抗或适应外界环境改变,而分化过程受控于由细胞因子和转录因子所组成的复杂调控网络。表观遗传学是研究不涉及DNA序列变化的DNA甲基化谱、染色质结构状态等对基因表达的改变,并在亲代与子代之间传递的一门科学。表观遗传对免疫细胞的分化调控和Th细胞亚群可遗传性等方面具有重要影响。 CD4＋helper T cells（ Th cells） differentiate into different cell subsets in order to resist or adapt to the environment changes under the condition of antigen stimulation and body micro-environment,and the process of cells differentiation is controlled by the complex regulatory network of cytokines and transcription factors. Epigenetics is a science that does not involve the change of DNA sequences and changes gene expression such as DNA methylation and chromatin structure,and passes between the parental and filial generation. Epigenetics have an important influence on the differentiation regulation of immune cells and the heritability of T helper cell lineage.
作者 淮文英 杨福权 唐玉琴 张天娥 刘伟伟
机构地区 成都中医药大学基础医学院
出处 《生物学杂志》 CAS CSCD 2016年第4期70-72,共3页 Journal of Biology
基金 国家自然基金(NO.81072727)
关键词 表观遗传学 TH细胞 分化 epigenetics T helper cells differentiation
分类号 R392.13 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1OESTREICH K J,WEINMANN A S.Transcriptional mechanisms that regulate T helper 1 cell differentiation[J].Curr Opin Immunol,2012,24(2):191-195.
  • 2VAHEDI G,C POHOLEK A,HAND T W,et al.Helper T Cell identity and evolution of differential transcriptomes and epigenomes[J].Immunol Rev,2013,252(1):24-40.
  • 3ZHU J,YAMANE H,PAUL W E.Differentiation of effector CD4+T cell populations[J].Annu Rev Immunol,2010,28:445-489.
  • 4ZHU J,PAUL W E.Peripheral CD4+T cell differentiation regulated by networks of cytokines and transcription factors[J].Immunol Rev,2010,238:247-262.
  • 5SCHULZ E G,MARIANI L,RADBRUCH A,et al.Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12[J].Immunity,2009,30(5):673-683.
  • 6YANG Y,OCHANDO J C,BROMBERG J S,et al.Identification of a distant T-bet enhancer responsive to IL-12/STAT4 and IFNgamma/STAT1signals[J].Blood,2007,110(7):2492-2500.
  • 7SCHOENBORN J R,DORSCHNER M O,SEKIMATA M,et al.Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma[J].Nat Immunol,2007,8(7):732-742.
  • 8SHI M,LIN T H,APPELL K C,et al.Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation[J].Immunity,2008,28(6):763-773.
  • 9徐涛,万传君,王建校,李珊珊,顾永清.CHD4在染色体重塑中的作用[J].现代生物医学进展,2014,14(7):1385-1387. 被引量：1
  • 10SHAHBAZIAN M D,GRUNSTEIN M.Functions of site-specific histone acetylation and deacetylation[J].Annu Rev Biochem,2007,76(1):75-100.

二级参考文献21

  • 1Urquhart A J, Gatei M, Richard D J, et al. ATM mediated phosphory- lation of CHD4 contributes to genome maintenance[J]. Genome hate- gr, 2011, 2(1): 1-10.
  • 2Larsen DH, Poinsignon C, Gudjonsson T, et al. The chromatin- remodeling factor CHD4 coordinates signaling and repair after DNA damage[J]. J Cell Biol, 2010, 190 (5): 731-740.
  • 3Polo SE, Kaidi A, Baskcomb L, et al. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodeling factor CHIM[J]. EMBO, 2010, 29(18): 3130-3139.
  • 4Magdalena Murawska, Alexander Brehm. CHD chromatin remodelers and the transcription cycle[J]. Transcription, 2011, 2(6): 244-253.
  • 5Mansfield RE, Musselman CA, Kwan AH, et al. Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with prefe- rence for unmodified H3K4 and methylated H3K9 [J]. Biol.Chem., 2011,286(13): 11779-11791.
  • 6Musselman, C. A, Mansfield, R. E, Garske, A. L. et al. Binding of the CHD4 PHD2 finger to histone H3 ismoduiated by covalent modifica- tions[J]. Biochem J, 2009, 423(2): 179-187.
  • 7Shi, X, Hong, T, Waiter, K. L, et al. 1NG2 PHD domain links histone H3 lysine4 methylation to active gene repression[J]. Nature, 2006, 44 2(7089): 96-99.
  • 8Musselman, C. A, Ramirez, J, Sims, J. M, et al. Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression [J]. Proc Natl Acad Sci USA, 2012, 109(3): 787-792 Double chromodomains cooperate to recognize the methylated histone H3 tail [J]. Nature, 2005, 438(7071): 1181-1185.
  • 9Flanagan, J. F, Mi, L. Z, Chruszcz, M, Cymborowski M, et al.
  • 10Flanagan JF, Blus B J, Kim D, et al. Molecular implications of evolu- tionary differences in CHD double chromodomains[J]. Biol, 2007, 36 9(2): 334-342.

同被引文献44

引证文献4

二级引证文献30

生物学杂志
2016年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部