动机对反应攻击的调制作用——基于静息态fMRI的个体差异研究

The effect of intentionality on reactive aggression:a rs-fMRI study on individual differences

目的采用泰勒范式并结合静息态功能磁共振成像技术研究他人动机对反应攻击调制的个体差异的神经机制。材料与方法共计30名健康男性被试参与本研究。在任务中,被试与4个对手轮流进行竞争反应时比赛,输的人被赢的人惩罚。这4个对手分别设置为:故意的高、低攻击对手和无意的高、低攻击对手。本研究采用被试给故意和无意高攻击对手惩罚强度的差值来量度动机对个体反应攻击的调制效应(动机效应)。使用DPARSF处理采集到的静息态数据,并将动机效应与静息状态下大脑的局部一致性(regional homogeneity,Re Ho)做相关分析。结果右侧颞顶联合区的Re Ho值与动机效应呈正相关;右侧纹状体的Re Ho值与动机效应呈负相关。结论这些数据表明颞顶联合区和纹状体与动机对反应攻击的调制作用有关。

Objective：To study the neural basis of individual differences in the effect of other＇s intentionality on individual＇s reactive aggression,we used a variant of taylor aggression paradigm（TAP）,with resting-state functional magnetic resonance imaging（rs-f MRI） technology.Materials and Methods：Our experiment recruited thirty healthy male volunteers.These participants played successive competitive reactiontime tasks with four opponents in turn and the loser who responded more slowly would be punished by the winner.The four opponents were comprised of intentional high-aggressive opponent,intentional low-aggressive opponent,unintentional highaggressive opponent and unintentional low-aggressive opponent.The effect of other＇s intentionality on individual＇s reactive aggression（i.e.the effect of intentionality） was measured by the difference in punishment intensity which participant gave to the intentional high-aggressive opponent and unintentional high-aggressive opponent.The rs-f MRI data was processed using DPARSF toolbox.Then correlation analysis was conducted to examine the relationship between the effect of intentionality and Re Ho values.Results：Significant positive correlations between the effect of intentionality and Re Ho values were observed in the temporo-parietal junction.Significant negative correlations between the effect of intentionality and Re Ho values were observed in the striatum.Conclusion：The data indicates that temporo-parietal junction and striatum are involved in the effect of other＇s intentionality on individual＇s reactive aggression.