唑来膦酸针与伊班膦酸钠针治疗骨肿瘤临床对比研究

Comparative Study of Zoledronic Acid and Ibandronate Sodium in Treat-ment of Bone Tumors

目的对比分析唑来膦酸针与伊班膦酸钠针治疗骨肿瘤的效果。方法方便选取2012年2月—2015年4月该院接收的62例骨肿瘤患者作为研究对象,随机分为观察组与对照组,各31例。对照组采用唑来膦酸针治疗,观察组采用伊班膦酸钠针治疗,对比观察两组患者疼痛缓解情况及不良反应发生率。结果观察组疼痛缓解总有效率93.55%明显高于对照组的70.98%,差异有统计学意义(P<0.05);观察组不良反应总发生率为6.45%,对照组为32.26%,两组对比差异有统计学意义(P<0.05)。结论采用伊班膦酸钠针治疗骨肿瘤患者效果显著优于唑来膦酸针,且不良反应发生率低,具有一定安全性,值得推广运用。

Objective To compare the efficacy of zoledronic acid and ibandronate sodium for treatment of bone tumor effect. Methods A total of 62 patients From February 2012 to April 2015 with bone tumors in our hospital were randomly divided into observation group and control group, 31 cases in each group.The control group was treated with zoledronic acid therapy, the observation group was treated with ibandronate sodium therapy.The pain relief and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of pain relief in the observation group was 70.98%higher than that in the control group （93.55%）, and the difference was statistically significant （P﹤ 0.05）;The incidence rate of adverse reactions in the observation group was 6.45%, the control group was 32.26%, and the difference was statistically significant （P﹤0.05）. Conclusion Ibandronate sodium treatment of bone tumor patients is significantly superior to that of a-zole zoledronic acid and adverse reactions occurred rate is low, have a certain safety. It is worthy of popularization and ap-plication.