围手术期强化他汀治疗对肾动脉狭窄介入治疗后炎性因子及肾功能的影响

Effect of Perioperative Intensive Statin Therapy on Inflammatory Factors and Renal Function after Interventional Treatment of Renal Artery Stenosis

目的探究围手术期中强化他汀治疗对肾动脉狭窄介入治疗后的炎性因子以及肾功能方面的影响。方法方便选取菏泽鲁心医院、济南市中心人民医院等院于2013年12月—2016年3月接受肾动脉狭窄手术治疗的患者280例,采用随机分组的方式将患者平均分成实验组和观察组,在手术前后分别观察患者的炎性因子水平以及反映肾功能的指标,并对两组患者进行对比分析。结果在围手术期中采用强化他汀治疗的实验组患者的CRP、IL-6的值、炎性因子水平分别(5.17±2.07)、(25.58±3.96)和(163.67±5.31),而采用常规治疗的对照组中的CRP、IL-6、血肌酐值在手术后的值分别为(6.35±1.95)、(32.12±4.73)和(169.75±5.19),手术后CRP、IL-6的值,血肌酐值水平差异有统计学意义,P<0.05。结论在围手术期中强化他汀治疗有助于对肾动脉狭窄介入治疗后炎性因子及肾功能的改善,具有显著疗效。

Objective To explore the perioperative intensive statin therapy on inflammatory factors after interventional treat-ment of renal artery stenosis and renal function.Methods A total in Heze heart hospital, Jinan City People＆#39;s Hospital, school accept 280 cases of patients from December 2013 to March 2016 with renal artery stenosis Surgical treatment, using ran-domized patients were divided into the experimental group and the observation group, before and after the operation were observed in patients with inflammatory factor level and index of renal function, and carries on the comparative analysis of two groups of patients. Results In the peri operation period of the reinforcement value of CRP and interleukin-6 in statin treated patients in the experimental group, inflammatory factor levels were （5.17±2.07）, （25.58±3.96） （163.67±5.31）, and the conventional treatment control group of CRP, IL-6, serum creatinine value in the postoperative values were （6.35 ±1.95）, （32.12±4.73）、 （169.75±5.19）, value of CRP and IL-6 after surgery, blood creatinine value level with significant difference （P﹤0.05）. Conclusion Intensive statin therapy in perioperative period is helpful to the improvement of inflammatory factors and renal function after interventional treatment of renal artery stenosis.