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纳米级胰岛素颗粒的制备和使用

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摘要 目的通过使用逆相蒸发法制备胰岛素脂质体颗粒,对颗粒进行壳聚糖外壳包裹并做进一步的颗粒粒径,包封率和稳定性的测试。结果所制备的胰岛素亚微球颗粒粒径范围为(451.1±46.1)nm,包封率为61.4%,颗粒在水相和油相溶液中均结构稳定。通过大鼠肠道吸收测试,有效降低血糖浓度。结论壳聚糖包裹胰岛素脂质体包封效果良好,粒径稳定并且能够口服后有效降低血糖浓度。
作者 梁华丽
出处 《中国医药指南》 2016年第23期40-41,共2页 Guide of China Medicine
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