注射用丹参多酚酸盐临床应用探讨

目的：研究探讨注射用丹参多酚酸盐对治疗心绞痛、脑梗化、冠心病等有临床作用。方法：通过注射用丹参多酚酸盐治疗心绞痛,治疗10~14d后,根据心绞痛发作次数和硝酸甘油用量的变化情况作为评价指标;在治疗脑梗化临床案例中,通过对比研究患者临床疗效的变化和舒张压和脑脊液对比变化作为评价指标;在治疗冠心病的临床试验中,通过疗效对比研究和硝酸甘油用量变化的临床数据分析研究做为评价指标。结果：在心绞痛治疗过程中,经过治疗10~14d后,大于75岁组心绞痛发作次数由治疗前的4.0次/周下降至治疗后1.0次/周,硝酸甘油的量也减半;在治疗脑梗化14d后,比较临床疗效、血压舒张压和脑脊液压力等指标的变化,评价结果为治疗组的总有效率为88.9%,对照组的总有效率为76.0%,治疗后两组的脑脊液和舒张压压力明显下降;在治疗冠心病临床治疗中,注射用丹参多酚酸盐可明显改善冠心病的临床症状、心电图,减少速效扩冠药物的用量。结论：注射用丹参多酚酸盐的治疗领域——主要治疗冠心病稳定型心绞痛,同时对脑血栓形成有预防作用,可治疗急性脑梗死,为医护人员提供一定的参考。

Objective：To investigate the clinical effect of injection salvianolate for treatment of angina pectoris, cerebral infarction of coronary heart disease and so on. Method：by injection salvianolate treatment of angina pectoris, for 10 days to 14 days, according to the changes of angina attacks and nitroglycerin amount as an evaluation index; in the case of cerebral infarction clinical treatment, clinical efficacy studies in patients by comparison and diastolic blood pressure changes and changes in cerebrospinal fluid as a comparative evaluation;clinical trials in the treatment of coronary heart disease, the clinical study data analysis and comparative study of the efficacy of nitroglycerin amount of change as the evaluation index. Results：angina episodes in the course of treatment, 10 to 14 days after treatment, more than 75-year-old group of angina decreased from 4.0 times the pre-treatment/week after treatment to 1.0 times/week, also halved the amount of nitroglycerin; in the treatment of cerebral infarction for 14 days, the change in comparative clinical efficacy, diastolic blood pressure and cerebrospinal fluid pressure and other indicators of evaluation results for the treatment group total effective rate of 88.9%, total effective rate of 76.0% in the control group, two groups after treatment of cerebrospinal fluid and diastolic pressure pressure decreased significantly;in the treatment of coronary heart disease in clinical treatment, an injection salvianolate can significantly improve the clinical symptoms of coronary heart disease, ECG, reduce the amount of fast-acting drugs spreading crown. Conclusion：Salvia injection therapeutic areas polyphenol salt - the main treatment for stable angina, and cerebral thrombosis have a preventive effect, treat cerebral infarction, provide a reference for health care workers.