摘要
目的:探讨肝素结合蛋白(HBP)与1,25-(OH)_2D_3在慢性阻塞性肺疾病急性加重期(AECOPD)患者血清中的表达水平及临床意义。方法:选择2012年7月至2015年7月广州医科大学附属第五医院收治的82例慢性阻塞性肺疾病患者作为研究对象,其中AECOPD组48例、COPD稳定期组34例。酶联免疫吸附试验测定1,25-(OH)_2D_3、HBP水平,同时检测血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及WBC水平,同步行肺功能及相关检查。结果:AECOPD患者HBP水平为(74.15±13.24)ng/m L,明显高于COPD稳定期患者的(51.57±10.22)ng/m L(P<0.05);AECOPD患者1,25-(OH)_2D_3水平为(14.85±5.32)ng/m L,明显低于COPD稳定期患者的(19.46±6.52)ng/m L(P<0.05)。AECOPD患者PCT、hs-CRP及WBC水平均高于COPD稳定期患者(P<0.05),肺功能各项指标均明显低于COPD稳定患者(P<0.05)。血清1,25-(OH)_2D_3与肺功能指标呈正相关,HBP水平与肺功能指标呈负相关(P<0.05)。结论:血清1,25-(OH)_2D_3、HBP可作为AECOPD的辅助诊断指标,二者在COPD气道炎症及重塑中可能具有重要作用。
Objective:To investigate serum expression levels and clinical significance of heparin binding protein (HBP) and 1,25-(OH)2D3 in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) . Methods:Included in this study were 82 COPD patients treated in the Fifth Affiliated Hospital of Guangzhou Medical University between July 2012 and July 2015. These subjects comprised AECOPD group ( n=48) and stable COPD group (n=34). Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of 1,25-(OH)2D3 and HBP. Meanwhile,the patients were examined for serum procalcitonin (PCT),high-sensitivity C-reactive protein (hs-CRP),WBC and pulmonary function. Results:The HBP level in AECOPD patients was(74.15±13.24) ng/mL,significantly higher than (51.57±10.22) ng/mL in the stable COPD patients (P〈0.05). The 1,25-(OH)2D3 level was (14.85±5.32) ng/mL in AECOPD patients,significantly lower than (19. 46±6.52) ng/mL in the stable COPD patients (P〈0.05). AECOPD patients had higher PCT,hs-CRP and WBC,and significantly lowered pulmonary function indexes,compared with stable COPD patients. Serum 1,25-( OH) 2 D3 level was positively correlated,while the HBP level was negatively correlated,with lung function indexes (P〈0.05). Conclusion:The serum 1,25-(OH)2D3 and HBP levels can be used as diagnostic markers for AECOPD. The both may be playing an important role in airway inflammation and remodeling in patients with COPD.
出处
《广州医科大学学报》
2016年第2期18-21,共4页
Academic Journal of Guangzhou Medical University
基金
广东省医学科学技术研究基金项目(A2015359)