游离胆红素对新生儿机体影响的研究进展

Research Progress of Free Bilirubin Effect on Neonatal Body

胆红素作为代谢产物广泛存在于机体体液、组织、器官中,其主要表现为两种形式,即游离胆红素和结合胆红素,临床也常称之为脂溶性胆红素和水溶性胆红素。目前发现胆红素在体内有着"双刃剑"的作用,即生理浓度的胆红素在体内发挥着积极的保护作用,而超生理浓度的胆红素却显现出诸多损害表现。但由于新生儿个体差异显著、合并症复杂、病情进展快等因素,使得在准确界定胆红素临界浓度方面变得尤为困难,考虑到当前高胆红素血症在临床发病率逐年升高且可导致严重的中枢神经损伤,该文就游离胆红素对新生儿的机体影响进行综述。

As a metabolite,hilirnbin is widely existing in body fluids,tissues and organs,mainly in two forms of free hiliruhin and conjugated bilirnbin, which can be referred to as fat soluble bilirnhin and water soluble bilirnhin in elinial. At present, the extensive research demonstrated that bilirubin in vivo has a double-edged sword fuentien. In brief,physiological concentration of bilirabin in the body plays an active role in the protection, while the ultra-physiological concentration of bilirubln has shown a lot of damaging effect. However, due to significant differences in individual newborns, complexity of the complications, rapid progres- sion and other factors,it＇s especially difficult for the precise defmition of critical concentration of hilirubin. Because currently the hyperhilimbinenda incidence has been increasing year by year which can lead to serious central nervous system damage ,here is to make a review of the effect of free bilirubin on the body of the newborils.