摘要
目前全世界肺癌的发病率显著增高,特别是在我国,肺癌的发病率居第一位。肺癌的5年生存率不高,其不良预后主要与肿瘤细胞的增殖、侵袭和转移有关。肺癌的发病机制复杂,是多因素、多基因、多阶段共同参与的结果。目前肺癌发病机制的基础研究已经取得一定成果,但与肺癌相关的增殖、侵袭性生物因子以及具体的作用机制却很少涉及。共济失调性毛细血管扩张D组互补基因(ATDC)参与细胞的生长、发育以及多种肿瘤的发生、发展。
Lung cancer is one of the leading causes of all cancer-related deaths worldwide and especially in China, and the incidence of lung cancer ranks the first among all tumors. Currently, the five-year survival rate of lung cancer is not high, and the poor prognosis of lung cancer is mainly related to tumor cell invasion and metastasis. The pathogenesis of lung cancer is complex,which is the result of multiple factors, genes, and stages. At present, much progress has been made in defining gene defects in lung cancer. But a full account- ing of its molecular pathogenesis remains to be provided. Ataxia telangietasia group D complement gene （ATDC） is involved in the cell growth, development and genesis and development of multiple tumors.
出处
《医学综述》
2016年第16期3172-3175,共4页
Medical Recapitulate
