2型糖尿病下肢血管病变潜在的生物标志物

Potential Biomarkers for Lower extremity Arterial Disease in Type 2 Diabetes Mellitus

下肢血管病变是2型糖尿病患者常见的动脉粥样硬化之一。炎性标志物人软骨糖蛋白39(HC-gp39/YKL-40)在肥胖、心血管疾病和2型糖尿病患者中水平升高,且YKL-40是胰岛素抵抗及动脉粥样硬化的炎性因子。生物标志物C反应蛋白已经被广泛用于评估动脉粥样硬化及炎症过程,但其并不是2型糖尿病患者胰岛素抵抗的生物标志物,而YKL-40在2型糖尿病患者胰岛素抵抗与动脉粥样硬化中起到了关键的作用。

Lower extremity arterial disease is a common complication of type 2 diabetes mellitus （T2DM）. The inflammatory biomarker Human cartilage glycoprotein-39 （HC-gp39/YKL-40） seems to play a role in atheroselerosis and is elevated in patients with obesity,cardiovascular disease and T2DM. YKL-40 is recognized as an inflammatory factor for insulin resistance and atherosclemsis. A recognized biolagleal marker, C-reactive protein, has been used widely to assess the progression of atherosclerosis and inflamma- tion,but not as an insulin resistance marker in T2DM patients, but YKL-40 may play significant roles in insulin resistance and atherosclerosis in T2DM patients.