硫酸金刚烷胺在社区群体性小儿流行性感冒病毒感染中的应用效果

Application Effect of Amantadine Sulfate for Treating Community Influenza Virus Infection in Children

目的 探讨硫酸金刚烷胺在社区群体性小儿流行性感冒（流感）病毒感染中的应用效果。方法 选择2013年10月至2015年2月首都医科大学昌平教学医院收治的昌平区群体性流感病毒感染患儿150例,根据随机抽签法分为观察组和对照组,各75例。在基础治疗基础上,对照组给予金刚烷胺治疗,每12小时按2.2~4.4 mg/kg口服,观察组给予硫酸金刚烷胺治疗,每12小时按2.2~4.4 mg/kg口服,治疗7 d。结果 观察组的总有效率显著高于对照组[97.3%（72/75）比89.3%（68/75）,P〈0.05]。观察组和对照组治疗后咳嗽症状评分均显著低于治疗前[（0.45±0.19）分比（2.87±0.11）分,（1.11±0.14）分比（2.86±0.10）分]（P〈0.05）,观察组的咳嗽症状评分显著低于对照组（P〈0.05）。观察组治疗后免疫球蛋白以及补体水平显著高于对照组（P〈0.05）;但观察组高敏C反应蛋白水平与对照组比较差异无统计学意义（P〉0.05）。治疗后观察组的生理功能、生理职能、躯体疼痛、总体健康评分显著高于对照组[（98±12）分比（92±9）分,（74±10）分比（52±11）分,（86±9）分比（70±11）分,（68±8）分比（61±10）分]（P〈0.05）。结论 硫酸金刚烷胺在社区群体性小儿流感病毒感染中的应用能有效改善改善流感病毒感染患儿的机体免疫功能,提高其生活质量。

Abstract： Objective To study the application effect of amantadine sulfate for treating community influ- enza virus infection in children. Methods Total of 150 children with influenza virus infection in Changping district community from Capital Medical University Teaching Hospital from Dee. 2013 to Feb. 2015 were included in the study and divided into an observation group and a control group according to the random draw method,75 cases each. The control group received amantadine treatment, orally taken every 12 hours by 2. 2- 4. 4 mg/kg;the observation group received amantadine sulfate treatment,orally taken every 12 hours by 2.2- 4. 4 mg/kg, both groups were treated for 7 days. Results The effective rate of the observation group was sig- nificantly higher than the control group[ 97.3% （ 72/75 ） vs 89.3% （ 68/75 ）, P 〈 0. 05 ]. After treatment cough symptom scores of observation group and control group were significantly lower than before [ （0. 45 ± 0. 19 ） point vs （2. 87 ± 0. 11 ） point, （ 1.11 ± 0. 14 ） point vs （2.86 ±0. 10 ） point ] （ P 〈 0. 05 ）, and the observation group was lower than the control group （ P 〈 0. 05 ）. The immunoglobulin, complement levels of the observation group after treatment were significantly higher than the control group （ P 〈 0. 05 ） ; but the high-sensitivity C-reactive protein（hs-CRP） levels in the two groups had no significant difference （P 〉 0. 05 ）. After treatment, the physiological function, physiological function, bodily pain and general health scores of the observation group were significantly higher than the control group[ （98 ±12） scores vs （92 ±9） scores, （74± 10） scores vs （52 ±11 ） scores, （86 ±9） scores vs （70 ± 11 ） scores, （68 ±8） scores vs （61 ± 10） scores ] （P 〈 0. 05 ）. Conclusion Amantadine sulfate can effectively improve immune function and improve the quality of life in treating community influenza virus infection in children.