依托芬那酯凝胶在急性带状疱疹疼痛治疗中的早期应用

Early Application of Etofenamate Gel in the Treatment of Acute Herpes Zoster Pain

目的观察依托芬那酯凝胶用于带状疱疹急性期的疗效及安全性。方法将2013年1月-2014年6月就诊的40例伴有剧烈疼痛[疼痛视觉模拟评分(VAS)≥7分]的急性带状疱疹患者随机分为对照组和治疗组,每组20例。对照组给予膦甲酸钠注射液+盐酸曲马多缓释片+加巴喷丁胶囊治疗;治疗组在对照组治疗方案上加用依托芬那酯凝胶疼痛区域外用(避开皮损部位)。于治疗2周后进行VAS评分及生活质量评分、睡眠质量评分、疼痛区域皮肤异感好转程度和皮损好转程度指标观察。结果治疗后,两组VAS均明显下降(P<0.05),治疗组治疗后VAS下降更为明显(P<0.05);治疗后,两组生活质量评分、睡眠质量评分和疼痛区域皮肤异感好转程度均有改善(P<0.05),且治疗组改善更明显(P<0.05);治疗后,两组皮损好转程度比较差异无统计学意义(P>0.05)。结论依托芬那酯凝胶早期应用于急性带状疱疹患者,可加强镇痛疗效,改善患者生活及睡眠质量,改善疼痛区域皮肤异感,安全性较好。

Objective To observe the efficacy and safety of etofenamate gel （foscavir＋tramadoli hydrochloridum＋gabapentin） in the treatment of acute herpes zoster. Methods Forty patients with acute herpes zoster neuralgia treated between January 2013 and June 2014 were randomly divided into two groups： control group and treatment group, with 20 in each. The patients had a visual analogue scale （VAS） pain score of seven or higher. Patients in the control group accepted conventional treatment, while those in the treatment group were treated with conventional treatment combined with etofenamate gel. Two weeks after treatment, VAS score, quality of life and sleep score, and the degree of improvement in skin paresthesia were evaluated and compared between the two groups. Results The VAS score decreased significantly in both the two groups after treatment （P 〈 0.05）, and the decrease in the treatment group was significantly more obvious （P 〈 0.05）. The quality of life, sleep score and the degree of improvement in skin paresthesia were ameliorated significantly after treatment （P 〈 0.05）, and the amelioration in the treatment group was significantly greater （P 〈 0.05）. Conclusion The early application of Ordofen can strengthen analgesia effect of the conventional treatment, improve the quality of life and sleep, and reduce skin paresthesia.