靶向肠道固有免疫系统和适应性免疫系统的药物开发与应用

Development and application of drugs targeting the innate and adaptive immune system in the colon

肠道固有免疫系统和T细胞介导的适应性免疫系统在炎症性肠病的发生、发展及转化中发挥着重要作用。炎症性肠病难以彻底治愈,但近年来针对肠道免疫系统的药物的开发和应用引起了极大的关注。其中靶向肠道固有免疫系统常见药物有:靶向肠道固有免疫信号传导、信号分子以及固有淋巴细胞的药物;靶向肠道适应性免疫系统的药物则有抑制肠道T细胞激活和分化,调节T细胞因子和T细胞平衡的药物。本文主要介绍了肠道固有免疫系统、适应性免疫系统以及靶向于肠道固有免疫系统和适应性免疫系统的药物研究等4个方面,并对未来的靶向肠道免疫系统药物的开发和应用进行了展望。

Recent advances in immunology and genetics have verified that the innate immune and adaptive immune responses that mediated by T cells, have been considered to play an important role in inducing inflamma- tory bowel disease. It＇ s difficult to cure the disease due to the complexity of the disease. However, the develop- ment and application of medicine, which target the immune response in the colon, attract great attention in recent years. In present, there are two types of targeting drugs in the intestinal immune systems： one of them targets the intestinal innate immune system, which includes targeting signal transduction, signal molecule and lymphocytes while the other targets adaptive immune system that includes inhibition of intenstinal T cell activation, differentia- tion and regulation of T cell cytokines and balance of T cell. This article mainly gives a comprehensive overview in four aspects, which include the intestinal innate immune response, adaptive immune response, drugs targeting in the intestinal innate and adaptive immune response. Furthermore, research directions are also pointed out in the review.