阿尔茨海默病与白内障

Alzheimer＇s disease and cataracts

阿尔茨海默病（AD）是一种进行性的与年龄相关的神经系统变性疾病，作为老年痴呆性疾病中最常见的类型，目前仍无有效的早期诊断方法和手段。AD病理表现为细胞内的淀粉样斑块及细胞外的神经纤维缠结。过度聚集的β淀粉样蛋白（Aβ）是导致AD发病的中心环节。AD患者除了记忆及认知功能障碍，尚有眼部症状。有研究发现，A口不仅在脑内发生沉积，也可在晶状体内发生类似改变。而晶状体结构及位置的特殊性，决定了其具有大脑不具备的可直观检查的优越性，可为AD的早期诊断提供简单方便快捷的方法。因此，值得引起重视及深入探究内在的具体关联。

Alzhelmer s disease （AD） is an age-related progressive neurodegenerative disease. As the most common type of senile dementia disease, AD has no effective methods for early diagnoses. AD is characterized by the deposition of intracellular amyloid-β （Aβ） plaques and extracellular neurofibrillary tangles （NFT） in the brain. In addition to allomnesia and cognitive disorder, ocular manifestation such as cataracts exists in AD patients. Studies have shown that amyloid-β （Aβ） is deposited not only in the brain but also in crystalline lens. For its structure and special location, crystalline len is more accessible for imaging than the brain, which can provide a simple, convenient and early diagnosis method for AD. Hence, it is worth investigating the relationship between Alzheimer＇s disease and cataracts.