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阿尔茨海默病与白内障 被引量:1

Alzheimer's disease and cataracts
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摘要 阿尔茨海默病(AD)是一种进行性的与年龄相关的神经系统变性疾病,作为老年痴呆性疾病中最常见的类型,目前仍无有效的早期诊断方法和手段。AD病理表现为细胞内的淀粉样斑块及细胞外的神经纤维缠结。过度聚集的β淀粉样蛋白(Aβ)是导致AD发病的中心环节。AD患者除了记忆及认知功能障碍,尚有眼部症状。有研究发现,A口不仅在脑内发生沉积,也可在晶状体内发生类似改变。而晶状体结构及位置的特殊性,决定了其具有大脑不具备的可直观检查的优越性,可为AD的早期诊断提供简单方便快捷的方法。因此,值得引起重视及深入探究内在的具体关联。 Alzhelmer s disease (AD) is an age-related progressive neurodegenerative disease. As the most common type of senile dementia disease, AD has no effective methods for early diagnoses. AD is characterized by the deposition of intracellular amyloid-β (Aβ) plaques and extracellular neurofibrillary tangles (NFT) in the brain. In addition to allomnesia and cognitive disorder, ocular manifestation such as cataracts exists in AD patients. Studies have shown that amyloid-β (Aβ) is deposited not only in the brain but also in crystalline lens. For its structure and special location, crystalline len is more accessible for imaging than the brain, which can provide a simple, convenient and early diagnosis method for AD. Hence, it is worth investigating the relationship between Alzheimer's disease and cataracts.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2016年第8期910-912,共3页 Chinese Journal of Geriatrics
基金 中南大学湘雅医院临床科研基金项目(2015110)
关键词 阿尔茨海默病 淀粉样Β蛋白 白内障 Alzheimer's disease Amyloid beta-protein Cataract
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