P糖蛋白与难治性癫痫关系的研究进展

Research progress on the relationship between P glycoprotein and intractable epilepsy

作为ATP-结合盒跨膜转运蛋白的其中一员,P糖蛋白(P-gp)扮演着清除外源生命体和细胞毒素的生理屏障角色。它在人体组织中分布广泛,功能多样,充当血脑屏障破坏后的第二屏障。研究发现,P-gp与难治性癫痫(RE)密切相关,是RE的主要发病机制之一,是国内外研究的热点。本文通过综述P-gp的结构、分布、生物学功能、调控机制及其与RE的关系,为RE的靶向治疗提供新的理论依据,对提高RE的防治水平具有重要价值。

As a member of ATP-binding cassette transmembrane transport protein, P-glycoprotein （P-gp）plays a role as a physiological barrier to removing exogenous and cellular toxins. P-gp is widely distributed in the human body and has a lot of functions, which acts as the second barrier after the destruction of blood brain barrier. Studies have found that P-gp is closely related to refractory epilepsy（RE） and it is one of the main pathogenesis of RE, which is a hot research topic at home and abroad. The structure, distribution, biological function and regulation mechanism of P-gp and its relationship with RE refractory epilepsy were reviewed in this paper, which can provide a new theoretical basis for the targeted therapy of RE and is of great value in improving the level： of prevention and treatment of RE.